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Search Result

Search Results for " pf-4 "

Targets

Glucagon Receptor

23

Compounds

38

Recombinant Proteins

Cat No. Product Name Synonyms Targets
TQ0239 PF-06291874 Glucagon receptor antagonists-4 Glucagon Receptor
PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor.
T19814 CP-380736 PF 00520893,CP380736,PF00520893,CP 380736,PF-00520893 EGFR
CP-380736 (PF-00520893) is an epidermal growth factor receptor (EGFR) inhibitor. EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer.
T5508 PF-AKT400 AKT protein kinase inhibitor Akt
PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.
T17169 Trk-IN-4 PF-6683324 isomer Trk receptor
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively).
TP2466 Platelet factor 4 (59-70) PF4 (59-70)
Platelet factor 4 (59-70) elicits human neutrophil & monocyte chemotaxis.
TP1885 [(pF)Phe4]Nociceptin(1-13)NH2
Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronocicep...
T69526 PF-07258669 Melanocortin Receptor
PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.
T2001 PF-573228 PF 573228 Apoptosis , FAK
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
T16481 PF-04995274 5-HT Receptor
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a...
TQ0167 Zimlovisertib PF-06650833,PF06650833 IRAK
Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay).
T6514 Glasdegib PF-04449913 Hedgehog/Smoothened , Smo
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
T9458 PF-00835231 SARS-CoV
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CLpro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CLpro, respectively.PF-00835231 is the active compound of the first anti-3CLpro regimen i...
T76705 Utomilumab PF 05082566,PF-2566 TNF
Utomilumab (PF 05082566) is a humanized IgG2 antibody targeting the T-cell co-stimulatory receptor 4-1BB/CD137 and a 4-1BB/CD137 agonist.Utomilumab has antitumor activity and may be used in the study of patients with adv...
T19649 PF-06273340 PF 6273340,PF 06273340,PF6273340,PF-6273340 Trk receptor
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflu...
T4230 PF-3758309 hydrochloride PF-03758309 hydrochloride Apoptosis , PAK
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...
T41275 PF-04753299 Others
PF-04753299 is a potent and selective inhibitor of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC), demonstrating bactericidal effects against gonococcal isolates. It exhibits inhibitory activity aga...
T28369 PF-06278121 PF6278121,PF 6278121,PF-6278121
PF-06278121 is a potent and selective Trk inhibitor. PF-06278121 shows Trk A/B IC50 = 4/94 nM (enzymatic assay), Trk A/B/C IC50 = 13/7/6 nM (PathHunter cell assay).
T12415 PF-00446687 Others
PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).
TP1667 Platelet Factor 4 (58-70), human
Platelet Factor 4 (58-70), human is a polypeptide based on the 58-70 amino acid sequence of Platelet Factor 4 (pf-4) residues.
T39248 PF-06426779
PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.
T60921 PF-07038124
PF-07038124 is an inhibitor of PDE4. The IC50 value of PF-07038124 for PDE4B2 is 0.5 nM. PF-07038124 shows inhibitory activities against IFNγ, IL4, and IL-13 with IC50 values of 1.06, 4.1, and 125 nM, respectively [1].
T70896 PF05020182
PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemic...
T11606 ICA-105665 PF-04895162 Others
ICA-105665 (PF-04895162) is a potent and orally active neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels opener. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function an...

Recombinant Proteins

Species：
Human (34)
Mouse (2)
Human,Cynomolgus (1)
Sus scrofa (Pig) (1)
Expression System：
HEK293 Cells (24)
E. coli (11)
Baculovirus Insect Cells (3)
Tag：
C-His-Avi (6)
Tag Free (6)
C-6xHis (5)
C-hFc (5)
His, GST (3)
C-His (2)
His (2)
N-His-Avi (2)
N-hFc (2)
His, Avi (1)
Cat No. Product Name Species Expression System
TMPY-00741 CXCL4 Protein, Human, Recombinant Human E. coli
Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds w...
TMPK-00014 CXCL4 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 a...
TMPK-00012 CXCL4 Protein, Human, Recombinant (His & Avi) Human E. coli
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 a...
TMPK-00013 CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylated Human E. coli
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 a...
TMPK-01248 CXCL4 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 a...
TMPJ-00012 CXCL4 Protein, Human, Recombinant (His) Human HEK293 Cells
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with hi...
TMPH-03121 CXCL4 Protein, Pig, Recombinant (His & Myc) Sus scrofa (Pig) E. coli
Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophil...
TMPJ-00864 VEGF165 Protein, Human, Recombinant Human HEK293 Cells
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator...
TMPY-00749 FGF-2 Protein, Human, Recombinant Human E. coli
FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPK-00823 VEGF165 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPY-04911 VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated Human,Cynomolgus HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 23.1 kDa and the accession number is P15692-4.
TMPY-04471 APEG1 Protein, Human, Recombinant (His) Human E. coli
Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr pr...
TMPY-02893 NT5C3A/NT5C3 Protein, Human, Recombinant Human E. coli
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded prot...
TMPK-00423 CD45 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPK-00822 VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most a...
TMPY-04754 CASK Protein, Human, Recombinant Human Baculovirus Insect Cells
CASK Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 102.1 kDa and the accession number is O14936-4.
TMPY-01822 PTK9 Protein, Human, Recombinant (His & GST) Human E. coli
PTK9 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 57 kDa and the accession number is Q12792-4.
TMPK-00424 CD45 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) com...
TMPJ-00782 Amyloid Precursor Protein, Human, Recombinant (hFc) Human HEK293 Cells
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and...
TMPY-00380 ANTXR2 Protein, Human, Recombinant (hFc) Human HEK293 Cells
ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4.
TMPJ-00410 CD45R0 Protein, Human, Recombinant (His) Human HEK293 Cells
CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
TMPJ-00233 CD200R1/CRTR2 Protein, Human, Recombinant (His) Human HEK293 Cells
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain ...
TMPY-01117 MRAP Protein, Human, Recombinant (hFc) Human HEK293 Cells
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,...
TMPY-01033 IL-32 Protein, Human, Recombinant (isoform alpha, His) Human HEK293 Cells
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathw...
TMPY-05598 Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293 Cells
Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 103.7 kDa and the accession number is P20273-4.
TMPJ-01333 TEM8/ANTXR1 Protein, Human, Recombinant (His) Human HEK293 Cells
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothel...
TMPY-00711 CD45 Protein, Human, Recombinant (hFc) Human HEK293 Cells
CD45 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.1 kDa and the accession number is P08575-4.
TMPK-00702 ANTXR2 Protein, Human, Recombinant (His) Human HEK293 Cells
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultu...
TMPY-04565 SRPK3 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 an...
TMPJ-01188 CORO6 Protein, Human, Recombinant (His) Human E. coli
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are...
TMPY-01823 PTK9 Protein, Human, Recombinant Human E. coli
PTK9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29 kDa and the accession number is Q12792-4.
TMPY-00225 CLEC9A Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
CLEC9A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.1 kDa and the accession number is Q8BRU4-4.
TMPJ-01256 Caspase-10 Protein, Human, Recombinant (His) Human E. coli
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granz...
TMPY-04563 CASK Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
CASK Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 130 kDa and the accession number is O14936-4.
TMPY-01933 CHI3L2 Protein, Human, Recombinant (His) Human HEK293 Cells
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, follo...
TMPY-00119 FLT1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is P17948-4.
TMPK-01356 SIRP alpha V4 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
TMPK-01362 SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl...
CXCL4 Protein, Human, Recombinant
TMPY-00741
Species: Human
Expression System: E. coli
CXCL4 Protein, Human, Recombinant (hFc)
TMPK-00014
Species: Human
Expression System: HEK293 Cells
CXCL4 Protein, Human, Recombinant (His & Avi)
TMPK-00012
Species: Human
Expression System: E. coli
CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00013
Species: Human
Expression System: E. coli
CXCL4 Protein, Mouse, Recombinant (hFc)
TMPK-01248
Species: Mouse
Expression System: HEK293 Cells
CXCL4 Protein, Human, Recombinant (His)
TMPJ-00012
Species: Human
Expression System: HEK293 Cells
CXCL4 Protein, Pig, Recombinant (His & Myc)
TMPH-03121
Species: Sus scrofa (Pig)
Expression System: E. coli
VEGF165 Protein, Human, Recombinant
TMPJ-00864
Species: Human
Expression System: HEK293 Cells
FGF-2 Protein, Human, Recombinant
TMPY-00749
Species: Human
Expression System: E. coli
VEGF165 Protein, Human, Recombinant (His & Avi)
TMPK-00823
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-04911
Species: Human,Cynomolgus
Expression System: HEK293 Cells
APEG1 Protein, Human, Recombinant (His)
TMPY-04471
Species: Human
Expression System: E. coli
NT5C3A/NT5C3 Protein, Human, Recombinant
TMPY-02893
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (His & Avi)
TMPK-00423
Species: Human
Expression System: HEK293 Cells
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
TMPK-00822
Species: Human
Expression System: HEK293 Cells
CASK Protein, Human, Recombinant
TMPY-04754
Species: Human
Expression System: Baculovirus Insect Cells
PTK9 Protein, Human, Recombinant (His & GST)
TMPY-01822
Species: Human
Expression System: E. coli
CD45 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00424
Species: Human
Expression System: HEK293 Cells
Amyloid Precursor Protein, Human, Recombinant (hFc)
TMPJ-00782
Species: Human
Expression System: HEK293 Cells
ANTXR2 Protein, Human, Recombinant (hFc)
TMPY-00380
Species: Human
Expression System: HEK293 Cells
CD45R0 Protein, Human, Recombinant (His)
TMPJ-00410
Species: Human
Expression System: HEK293 Cells
CD200R1/CRTR2 Protein, Human, Recombinant (His)
TMPJ-00233
Species: Human
Expression System: HEK293 Cells
MRAP Protein, Human, Recombinant (hFc)
TMPY-01117
Species: Human
Expression System: HEK293 Cells
IL-32 Protein, Human, Recombinant (isoform alpha, His)
TMPY-01033
Species: Human
Expression System: HEK293 Cells
Siglec-2/CD22 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPY-05598
Species: Human
Expression System: HEK293 Cells
TEM8/ANTXR1 Protein, Human, Recombinant (His)
TMPJ-01333
Species: Human
Expression System: HEK293 Cells
CD45 Protein, Human, Recombinant (hFc)
TMPY-00711
Species: Human
Expression System: HEK293 Cells
ANTXR2 Protein, Human, Recombinant (His)
TMPK-00702
Species: Human
Expression System: HEK293 Cells
SRPK3 Protein, Human, Recombinant (His & GST)
TMPY-04565
Species: Human
Expression System: Baculovirus Insect Cells
CORO6 Protein, Human, Recombinant (His)
TMPJ-01188
Species: Human
Expression System: E. coli
PTK9 Protein, Human, Recombinant
TMPY-01823
Species: Human
Expression System: E. coli
CLEC9A Protein, Mouse, Recombinant (hFc)
TMPY-00225
Species: Mouse
Expression System: HEK293 Cells
Caspase-10 Protein, Human, Recombinant (His)
TMPJ-01256
Species: Human
Expression System: E. coli
CASK Protein, Human, Recombinant (His & GST)
TMPY-04563
Species: Human
Expression System: Baculovirus Insect Cells
CHI3L2 Protein, Human, Recombinant (His)
TMPY-01933
Species: Human
Expression System: HEK293 Cells
FLT1 Protein, Human, Recombinant (hFc)
TMPY-00119
Species: Human
Expression System: HEK293 Cells
SIRP alpha V4 Protein, Human, Recombinant (His & Avi)
TMPK-01356
Species: Human
Expression System: HEK293 Cells
SIRP alpha V4 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-01362
Species: Human
Expression System: HEK293 Cells
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