Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

PF-3758309 hydrochloride

PF-3758309 hydrochloride
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
Catalog No. T4230Cas No. 1279034-84-2
Select Batch
Purity:100%
Contact us for more batch information
Resource Download

PF-3758309 hydrochloride

Catalog No. T4230Cas No. 1279034-84-2
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$44In Stock
10 mg$72In Stock
25 mg$115In Stock
50 mg$211In Stock
100 mg$332In Stock
1 mL x 10 mM (in DMSO)$70In Stock
Bulk & Custom
Add to Cart

Related Compound Libraries of "PF-3758309 hydrochloride"

Product Introduction

Bioactivity
Description
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
Targets&IC50
PAK4:18.7 nM (Ki), PAK4:2.7 nM (Kd), PAK3:99 nM (IC50), PAK1:13.7 nM (Ki), PAK2:190 nM (IC50), PAK6:17.1 nM (Ki), PAK5:18.1 nM (Ki)
AliasPF-03758309 hydrochloride
Chemical Properties
Molecular Weight527.08
FormulaC25H31ClN8OS
Cas No.1279034-84-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (85.37 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8972 mL9.4862 mL18.9725 mL94.8623 mL
5 mM0.3794 mL1.8972 mL3.7945 mL18.9725 mL
10 mM0.1897 mL0.9486 mL1.8972 mL9.4862 mL
20 mM0.0949 mL0.4743 mL0.9486 mL4.7431 mL
50 mM0.0379 mL0.1897 mL0.3794 mL1.8972 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy PF-3758309 hydrochloride | purchase PF-3758309 hydrochloride | PF-3758309 hydrochloride cost | order PF-3758309 hydrochloride | PF-3758309 hydrochloride chemical structure | PF-3758309 hydrochloride formula | PF-3758309 hydrochloride molecular weight