store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 49.00 | |
25 mg | 10-14 weeks | Inquiry | |
50 mg | 10-14 weeks | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 299.00 |
Description | PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1). |
Synonyms | PF 6273340, PF 06273340, PF6273340, PF-6273340 |
Molecular Weight | 479.92 |
Formula | C23H22ClN7O3 |
CAS No. | 1402438-74-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 90 mg/mL (187.53 mM)
Ethanol: 1 mg/mL (2.08 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-06273340 1402438-74-7 Tyrosine Kinase/Adaptors Trk receptor inhibit PF 6273340 PF 06273340 Trk Receptor PF6273340 Tropomyosin related kinase receptor Inhibitor PF-6273340 PF06273340 inhibitor