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PF-06273340

Catalog No. T19649   CAS 1402438-74-7
Synonyms: PF 6273340, PF 06273340, PF6273340, PF-6273340

PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).

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PF-06273340 Chemical Structure
PF-06273340, CAS 1402438-74-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 49.00
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50 mg 10-14 weeks Inquiry
1 mL * 10 mM (in DMSO) In stock $ 299.00
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Purity: 98.00%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10 6 cm s 1).
Synonyms PF 6273340, PF 06273340, PF6273340, PF-6273340
Molecular Weight 479.92
Formula C23H22ClN7O3
CAS No. 1402438-74-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 90 mg/mL (187.53 mM)

Ethanol: 1 mg/mL (2.08 mM)

TargetMolReferences and Literature

1. Skerratt SE, Andrews MD, Bagal SK, Bilsland J, Brown D, Bungay PJ, Cole S, Gibson KR, Jones R, Morao I, Nedderman A, Omoto K, Robinson C, Ryckmans T, Skinner K, Stupple PA, Waldron G. The Discovery of a Potent, Selective and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. J Med Chem. 2016 Oct 21. [Epub ahead of print] PubMed PMID: 27766865.

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Keywords

PF-06273340 1402438-74-7 Tyrosine Kinase/Adaptors Trk receptor inhibit PF 6273340 PF 06273340 Trk Receptor PF6273340 Tropomyosin related kinase receptor Inhibitor PF-6273340 PF06273340 inhibitor

 

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