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NT5C3A/NT5C3 Protein, Human, Recombinant

Catalog No. TMPY-02893
Synonyms: P5N1, P5N-1, hUMP1, NT5C3, cN-III, PSN1, UMPH1, UMPH, POMP, 5'-nucleotidase, cytosolic IIIA, P5'N-1, PN-I, p36

NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but not of its catalytic mutants, suppressed IL-8 production by HEK293 cells. NT5C3A-stimulated sirtuin activity resulted in deacetylation of histone H3 and the NF-kappaB subunit RelA (also known as p65), both of which were associated with the proximal region of the Il8 promoter, thus repressing the transcription of Il8 Together.

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NT5C3A/NT5C3 Protein, Human, Recombinant
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Biological Description
Technical Params
Product Properties
Description NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but not of its catalytic mutants, suppressed IL-8 production by HEK293 cells. NT5C3A-stimulated sirtuin activity resulted in deacetylation of histone H3 and the NF-kappaB subunit RelA (also known as p65), both of which were associated with the proximal region of the Il8 promoter, thus repressing the transcription of Il8 Together.
Species Human
Expression System E. coli
Tag Tag Free
Accession Number Q9H0P0-4
Synonyms P5N1, P5N-1, hUMP1, NT5C3, cN-III, PSN1, UMPH1, UMPH, POMP, 5'-nucleotidase, cytosolic IIIA, P5'N-1, PN-I, p36
Construction mature form of Human NT5C3 (NP_001002010) (Met 12-Leu 297)
Protein Purity > 92 % as determined by SDS-PAGE
Molecular Weight 32.7kDa (predicted)
Endotoxin Please contact us for more information.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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In general, Lyophilized powders are shipping with blue ice.

Research Background NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but not of its catalytic mutants, suppressed IL-8 production by HEK293 cells. NT5C3A-stimulated sirtuin activity resulted in deacetylation of histone H3 and the NF-kappaB subunit RelA (also known as p65), both of which were associated with the proximal region of the Il8 promoter, thus repressing the transcription of Il8 Together.

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Keywords

NT5C3A/NT5C3 Protein, Human, Recombinant P5N1 PSN 1 P5N-1 hUMP1 NT5C3 UMPH-1 cN-III PSN-1 PSN1 UMPH1 UMPH POMP 5'-nucleotidase, cytosolic IIIA P5'N-1 PN-I p36 UMPH 1 recombinant recombinant-proteins proteins protein

 

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