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Catalog No. T6514   CAS 1095173-27-5
Synonyms: PF-04449913

Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.

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Glasdegib Chemical Structure
Glasdegib, CAS 1095173-27-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
5 mg In stock $ 89.00
10 mg In stock $ 148.00
25 mg In stock $ 318.00
50 mg In stock $ 538.00
100 mg In stock $ 778.00
1 mL * 10 mM (in DMSO) In stock $ 97.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
Targets&IC50 Smo:5 nM
In vitro In vitro microsomal assays, PF-04449913 have high clearance in rat and low clearance in dog and human, without inhibiting any of the major cytochrome P450 isoforms. [1]
In vivo In rat and dog, PF-04449913 shows high clearance, and good oral bioavailability. [1]
Cell Research PF-04449913 is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. Normal or BC CML CD34+ cells are plated on confluent mitomycin-C treated SL/M2 cells with vehicle, PF-04449913 (1 μM), Dasatinib (50 nM), or combination treatment. Mouse bone marrow stromal cell lines, M2-10B4 (M2) and SL/SL (SL) are treated with mitomycin-C (1 mg/mL) and plated in a 1:1 mixture at a total concentration of 100,000 cells/mL one day prior to co-culture with 10,000-20,000 CD34+ BC CML or normal progenitors. After 1 week of culture, progenitors are FACS sorted into hematopoietic progenitor assays and colonies are scored at 14 days. To assess survival of normal human hematopoietic stem and progenitor cells, irradiated (20 Gray) OP9 (M2 clone) stromal cells are co-cultured with 50,000 human CD34+ cord blood cells, vehicle or PF-04449913 in AlphaMEM with 20% Hyclone FBS, 1% pen strep glutamine and supplemented with 50 ng/mL SCF, 10 ng/mL thrombopoietin, and 10 ng/mL Flt3 and quantified by weekly FACS analysis[1].
Synonyms PF-04449913
Molecular Weight 374.44
Formula C21H22N6O
CAS No. 1095173-27-5


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 44 mg/mL (117.5 mM)

TargetMolReferences and Literature

1. Munchhof MJ, et al. ACS Med Chem Lett. 2011, 3(2), 106-111.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library EMA Approved Drug Library Anti-Cancer Clinical Compound Library GPCR Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library

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Glasdegib 1095173-27-5 GPCR/G Protein Stem Cells Hedgehog/Smoothened Smo Inhibitor PF04449913 PF-04449913 inhibit Smoothened PF 04449913 inhibitor