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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11224 | Rineterkib | ERK-IN-1 | ERK , Raf |
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway. | |||
TN1721 | Gypenoside L | ERK , p38 MAPK , Calcium Channel , NF-κB , ROS | |
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... | |||
T7953 | BpV(HOpic) | bpV (HOpic) | PTEN |
BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM). | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T21980 | PD 198306 | MEK | |
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. | |||
T6427 | Butein | 2’,3,4,4’-tetrahydroxy Chalcone | Apoptosis , EGFR , Others , PDE , Autophagy |
Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR. | |||
T23046 | N-tert-butyl-α-Phenylnitrone | (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide | ROS , COX |
N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge... | |||
TN4114 | Gardenin A | ERK , LDL , MAPK , PKA , PKC | |
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects. | |||
T10383 | Asatone | NF-κB | |
Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK, and p38) pathways. | |||
T27242 | EF24 | EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone | ERK , MEK , Caspase |
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK. EF24 shows potent anti-tumor activity in oral ... | |||
T6277 | Doramapimod | BIRB 796 | Raf , p38 MAPK , Autophagy |
Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70. | |||
T3908 | 10-Gingerol | Apoptosis | |
10-Gingerol-induced apoptosis was accompanied by phosphorylation of the mitogen-activated protein kinase (MAPKs) family, p38 MAPK (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). | |||
T3636 | (E)-SIS3 | SIS3,SIS3 HCl | TGF-beta/Smad |
(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas... | |||
TN1880 | Lucidenic acid B | Lucidenicacid B | Apoptosis , Caspase |
Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mito... | |||
T6066 | SCH772984 | ERK , MEK | |
SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases. | |||
TN5888 | Toddaculin | Others | |
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in... | |||
T3398 | Icaritin | Anhydroicaritin,Cycloicaritin | Apoptosis , JAK , STAT , Autophagy |
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Ica... | |||
TN1485 | Chicanine | Others , NF-κB , Prostaglandin Receptor | |
Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways. | |||
T60821 | ACA-28 | ||
ACA-28 (compound 2a) is a potent modulator of ERK MAPK signaling that induces apoptosis with ERK hyperactivation therefore selectively inhibits cancer cell growth. The IC 50 values of ACA-28 against melanoma cells (SK-ME... | |||
TN2328 | Zeylenone | Apoptosis , ERK , MAPK , Akt , PI3K , mTOR | |
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signallin... |