Cart
Angiogenesis JAK Icaritin

Icaritin

Catalog No. T3398   CAS 118525-40-9
Synonyms: Anhydroicaritin, Cycloicaritin

Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. Icaritin at low concentration (4 or 8 μMol/L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Icaritin, CAS 118525-40-9
Pack Size Availability Price/USD Quantity
2 mg In stock 40.00
5 mg In stock 62.00
10 mg In stock 110.00
25 mg In stock 198.00
1 mL * 10 mM (in DMSO) In stock 68.00
Bulk Inquiry
Get quote
Select Batch  
Purity 97.69%
Purity 98.96%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Icaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. Icaritin at low concentration (4 or 8 μMol/L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.
Targets&IC50 JAK2 ,   STAT3
Synonyms Anhydroicaritin , Cycloicaritin
Purity 97.69%
Molecular Weight 368.38
Formula C21H20O6
CAS No. 118525-40-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 16 mg/mL(43.4 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
4. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2020 5. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2021, 19(1): 1-14.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Natural Product Library for HTS Anti-Cancer Compound Library Clinical Compound Library Stem Cell Differentiation Compound Library Apoptosis Compound Library Autophagy Compound Library Epigenetics Compound Library MAPK Inhibitor Library Immunology/Inflammation Compound Library Selected Plant-Sourced Compound Library Kinase Inhibitor Library Anti-Cancer Clinical Compound Library Polyphenolic Natural Product Library Angiogenesis related Compound Library JAK-STAT Compound Library Anti-Aging Compound Library Anti-Tumor Natural Product Library Chinese Pharmacopoeia Natural Product Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Immuno-Oncology Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Flavonoid Natural Product Library HIF-1 Signaling Pathway Compound Library Traditional Chinese Medicine Monomer Library Anti-Pancreatic Cancer Compound Library Anti-Fibrosis Compound Library

Related Products

Related compounds with same targets
Cucurbitacin I CHZ868 SH5-07 Abrocitinib Brepocitinib Colivelin CMD178 TFA Angoline

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.