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BpV(HOpic)

Catalog No. T7953 CAS 722494-26-0

Synonyms: bpV (HOpic)

bpV (HOpic) is a potent inhibitor of PTEN (IC50 of 14 nM).

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BpV(HOpic), CAS 722494-26-0

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Purity: 98%

Biological Description

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Description	bpV (HOpic) is a potent inhibitor of PTEN (IC50 of 14 nM).
Targets&IC50	PTEN:14 nM(Cell-free assay)
In vitro	1 μM BpV(Hopic) is capable of enhancing the migration of C2C12 myoblasts by approximately 40 % in the presence of myotube conditioned media, without significantly affecting their capacity to differentiate and fuse into multinucleated myotubes.?Improved migration of myoblasts treated with 1 μM BpV(Hopic) was associated with activation of PI3K/AKT and MAPK/ERK pathways, while their inhibition with either LY294002 or UO126, respectively, resulted in a reduction of C2C12 migration back to control levels[1]

Synonyms	bpV (HOpic)
Molecular Weight	347.235
Formula	C6H4K2NO8V
CAS No.	722494-26-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mM

DMSO: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Dimchev GA, Al-Shanti N, Stewart CE.Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways.J Muscle Res Cell Motil. 2013 May;34(2):125-36. 2. Schmid A C , Byrne R D , Ramón Vilar, et al. Bisperoxovanadium compounds are potent PTEN inhibitors[J]. Febs Letters, 2004, 566(1-3):0-38.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Lung Cancer Compound Library Inhibitor Library Kinase Inhibitor Library Stem Cell Differentiation Compound Library Apoptosis Compound Library Anti-Aging Compound Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

Related Products

Related compounds with same targets

Valinomycin Afzelin BpV(HOpic) VO-Ohpic trihydrate Ginkgolic acid C17:1 SF1670 Oroxin B Cucurbitacin B

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BpV(HOpic) 722494-26-0 PI3K/Akt/mTOR信号通路 PTEN MAPK/ERK Phosphatase and tensin homolog Inhibitor MMAC1 bpV (HOpic) inhibit PI3K/AKT signalling inhibitor

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