iκbα — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TD0099	Malachite green oxalate		Apoptosis , Others , IκB/IKK , NF-κB
	Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.		Apoptosis , Others , IκB/IKK , NF-κB
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T1934	Bay 11-7085	BAY 11-7083	Apoptosis , IκB/IKK , Ferroptosis , NF-κB
	Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).		Apoptosis , IκB/IKK , Ferroptosis , NF-κB
T1902	BAY 11-7082	BAY 11-7821	Apoptosis , Others , IκB/IKK , DUB , Autophagy
	BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).		Apoptosis , Others , IκB/IKK , DUB , Autophagy
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
T3384	Wedelolactone	IKK Inhibitor II	Apoptosis , NF-κB , Lipoxygenase , Caspase
	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.		Apoptosis , NF-κB , Lipoxygenase , Caspase
T2947	Indole-3-carbinol	I3C,3-Indolemethanol,Indole-3-Methanol	E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53
	Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T6141	IMD-0354	IKK2 Inhibitor V,IMD 0354	IκB/IKK
	IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.		IκB/IKK
T4237	Rubiadin-1-methyl ether	Rubiadin 1-methyl ether	Anti-infection , NF-κB
	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nu...		Anti-infection , NF-κB
T125120	Cyclo(L-Pro-L-Val)		IκB/IKK , NOS , NF-κB , COX , Antibacterial
	Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microo...		IκB/IKK , NOS , NF-κB , COX , Antibacterial
T13265	Urolithin B		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
	Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropical fruits, and medicinal herbs. Urolithin B inhibits NF-κB activit...		ERK , NF-κB , Akt , Endogenous Metabolite , JNK , AMPK
T5688	Micheliolide		NOS , NF-κB , COX
	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.		NOS , NF-κB , COX
T1930	JSH-23		NF-κB
	JSH-23, an NF-κB inhibitor（IC50= 7.1 μM）, suppresses the transcriptional activity.		NF-κB
T2913	Schisantherin A	Schisanwilsonin H,Gomisin-C,Wuweizi ester-A,Schizantherin-A,Arisanschinin K	NF-κB
	Schisantherin A (Wuweizi ester-A) is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent.		NF-κB
T5S2059	Glaucine		Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
T4S1615	Sanggenon C	Sanggenone C	NF-κB
	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...		NF-κB
T4S1469	Cucurbitacin IIb		Apoptosis , Others
	1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-i...		Apoptosis , Others
T7030	Anemarsaponin B		p38 MAPK , NF-κB , MEK , COX , NO Synthase
	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c...		p38 MAPK , NF-κB , MEK , COX , NO Synthase
T28210	NSC663627
	NSC663627 is an IκBα phosphorylation inhibitor.
T23693	AKCI
	AKCI is a PPI inhibitor that acts by targeting the AURKC-IκBα interaction.