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Wedelolactone

Name: Wedelolactone
Brand: TargetMol
SKU: T3384
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3384Cas No. 524-12-9

Alias IKK Inhibitor II

Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

Wedelolactone

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Purity: 99.87%

Catalog No. T3384Alias IKK Inhibitor IICas No. 524-12-9

Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$195	In Stock	In Stock
50 mg	$349	In Stock	In Stock
100 mg	$459	In Stock	In Stock
500 mg	$1,060	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Wedelolactone AI Summary

Wedelolactone demonstrates a wide array of bioactivities, including inhibitory effects on key enzymes and molecular interactions. It inhibits 5-lipoxygenase in pig leukocytes with an IC50 of 2500000.0 nM and shows inhibitory activity against rat kidney Na+, K+-ATPase and rat brain synaptosomes flunitrazepam binding with IC50 values of 700.0 nM and 2000.0 nM respectively. Additionally, it stabilizes various protein targets such as kinases (e.g., AMPKA2, CAMKs, CDKs, etc.) via thermal melting changes. It binds human recombinant carbonyl reductase 1 and 3 with a notable increase in melting temperature in the presence of NADP+, and shows inhibitory effects on NADPH oxidation (IC50 of 3780.0 nM, Ki of 600.0 nM). The compound also inhibits HCV 1b NS5B polymerase with an IC50 of around 36100.0 nM. It inhibits Borrelia burgdorferi telomere resolvase and exhibits binding affinity to EED with a dissociation constant (Kd) of 2820.0 nM. Moreover, Wedelolactone shows moderate inhibition of AChE and BChE at 2 mg/ml concentrations and influences G6PD activity in human cells. It's a potent inhibitor of organic cation transporters OCT1 and OCT2, with significant inhibitory activity on OCT1-mediated ASP+ uptake. These diverse bioactivities underscore the potential of Wedelolactone as a multifaceted chemical tool for biological research and therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.
Targets&IC50	5-LOX:2.5 μM (IC50)
Synonyms	IKK Inhibitor II

Chemical Properties

Molecular Weight	314.25
Formula	C₁₆H₁₀O₇
Cas No.	524-12-9
Smiles	COc1cc(O)c2c3oc4cc(O)c(O)cc4c3c(=O)oc2c1
Relative Density.	1.655 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (803.5 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5.7 mg/mL (18.14 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1822 mL	15.9109 mL	31.8218 mL	159.1090 mL
5 mM	0.6364 mL	3.1822 mL	6.3644 mL	31.8218 mL
10 mM	0.3182 mL	1.5911 mL	3.1822 mL	15.9109 mL
20 mM	0.1591 mL	0.7955 mL	1.5911 mL	7.9554 mL
50 mM	0.0636 mL	0.3182 mL	0.6364 mL	3.1822 mL
100 mM	0.0318 mL	0.1591 mL	0.3182 mL	1.5911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc