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Catalog No. T23693   CAS 669750-88-3

AKCI is a PPI inhibitor that acts by targeting the AURKC-IκBα interaction.

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AKCI Chemical Structure
AKCI, CAS 669750-88-3
Pack Size Availability Price/USD Quantity
5 mg 6-8 weeks $ 1,070.00
50 mg 6-8 weeks $ 2,180.00
100 mg 6-8 weeks $ 2,800.00
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AKCI is a PPI inhibitor that acts by targeting the AURKC-IκBα interaction.
Molecular Weight 369.46
Formula C19H27N7O
CAS No. 669750-88-3


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

TargetMolReferences and Literature

1. Patthy A, Molnár T, Porrogi P, Naudé R, Gráf L. Isolation and characterization of a protease inhibitor from Acacia karroo with a common combining loop and overlapping binding sites for chymotrypsin and trypsin. Arch Biochem Biophys. 2015 Jan 1;565:9-16. doi: 10.1016/j.abb.2014.11.001. Epub 2014 Nov 8. PubMed PMID: 25447841. 2. Ulu SM, Ahsen A, Akcı Ö, Yaman F, Demir K, Yaman G, Yüksel Ş, Acartürk G. The relationship between dipping-non-dipping arterial blood pressure pattern and frequency of restless leg syndrome with related factors. Anatol J Cardiol. 2015 Apr;15(4):284-8. doi: 10.5152/akd.2014.5381. Epub 2014 Apr 16. PubMed PMID: 25413225; PubMed Central PMCID: PMC5336836. 3. Han EH, Min JY, Yoo SA, Park SJ, Choe YJ, Yun HS, Lee ZW, Jin SW, Kim HG, Jeong HG, Kim HK, Kim ND, Chung YH. A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells. Oncotarget. 2017 Jun 29;8(41):69691-69708. doi: 10.18632/oncotarget.18883. eCollection 2017 Sep 19. PubMed PMID: 29050234; PubMed Central PMCID: PMC5642509.

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  • Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box


Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.


Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


AKCI 669750-88-3 inhibitor inhibit