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Rubiadin-1-methyl ether

Catalog No. T4237 CAS 7460-43-7

Synonyms: Rubiadin 1-methyl ether

Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Rubiadin-1-methyl ether Chemical Structure

Rubiadin-1-methyl ether, CAS 7460-43-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 590.00
25 mg	In stock	$ 943.00
50 mg	In stock	$ 1,270.00
1 mL * 10 mM (in DMSO)	In stock	$ 369.00

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Purity: 98.32%

Biological Description

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Storage & Solubility Information

Description	Rubiadin-1-methyl ether (Rubiadin 1-methyl ether) is a natural product.It inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.
In vitro	To search for anti-diabetic and insulin-sensitising natural products, the effect on adipocyte differentiation was investigated by assessing fat accumulation in 3T3-L1 preadipocytes using Oil Red O staining. METHODS AND RESULTS:Fractionation and separation of n-hexane and CHCl₃ fractions of Morinda officinalis (Rubiaceae) using several chromatographic methods led to the isolation of three anthraquinones, 1,2-dimethoxyanthraquinone (1), alizarin-2-methyl ether (2) and rubiadin-1-methyl ether (3). Among them, alizarin-2-methyl ether (2) showed the strongest enhancing activity, followed by Rubiadin 1-methyl ether (3) and 1,2-dimethoxyanthraquinone (1). At a concentration of 100 μM, alizarin-2-methyl ether (2) enhanced adipocyte differentiation by up to 131% (compared to insulin-treated cells). CONCLUSIONS:Thus, these compounds could be beneficial in the treatment of diabetes.
Source	Natural Products > Rubiaceae > Paederia

Synonyms	Rubiadin 1-methyl ether
Molecular Weight	268.26
Formula	C16H12O4
CAS No.	7460-43-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.68 mg/mL (10 mM), Sonication is recommended.

References and Literature

1. Anthraquinones from Morinda officinalis roots enhance adipocyte differentiation in 3T3-L1 cells. Nat Prod Res. 2012;26(18):1750-4. 2. Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum. Planta Med. 1992 Dec;58(6):533-4. 3. Natural anthraquinones probed as Type I and Type II photosensitizers: singlet oxygen and superoxide anion production. J Photochem Photobiol B. 2005 Jan 14;78(1):77-83.

Related compound libraries

This product is contained In the following compound libraries：

NF-κB Signaling Compound Library Anti-infective Natural Product Library Anti-Pancreatic Cancer Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Anti-Breast Cancer Compound Library Pyroptosis Compound Library RO5 Drug-like Natural Product Library Traditional Chinese Medicine Monomer Library Anti-Ovarian Cancer Compound Library Chinese Pharmacopoeia Natural Product Library

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Keywords

Rubiadin-1-methyl ether 7460-43-7 Microbiology/Virology NF-Κb NF-κB Anti-infection Inhibitor Nuclear factor-kappaB Nuclear factor-κB Rubiadin 1-methyl ether Rubiadin1methyl ether Rubiadin 1 methyl ether inhibit inhibitor

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