neurotoxicity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2550	Tolmetin	Tolectin	COX
	Tolmetin (Tolectin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds.		COX
T3S1873	Talatisamine		Potassium Channel
	1. Talatisamine (12 μM) and TEA (5mM) inhibits the enhanced I(K) caused by Aβ4 oligomers, attenuates cytotoxicity of Aβ oligomers by restoring cell viability and suppressing K(+) loss related apoptotic response. 2. Talat...		Potassium Channel
T36964	BML-259	CAY10554	CDK
	BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.		CDK
T0412	Idebenone	CV-2619	Apoptosis , Antioxidant , Mitochondrial Metabolism
	Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).		Apoptosis , Antioxidant , Mitochondrial Metabolism
T6780	Benzamide	Amid kyseliny benzoove,Phenylcarboxyamide,Benzoylamide	PARP , Endogenous Metabolite
	Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.		PARP , Endogenous Metabolite
T6500	Ferrostatin-1	Ferrostatin 1,Ferrostatin-1 (Fer-1)	Ferroptosis , Antifungal
	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and anti...		Ferroptosis , Antifungal
TN1736	Hibifolin		Adenosine deaminase
	Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.		Adenosine deaminase
T2264	AM281		Cannabinoid Receptor
	AM 281, a cannabinoid antagonist, reduces neurologic dysfunction and mortality rate after cecal ligation and puncture in rats.		Cannabinoid Receptor
T9454	4-Hydroxyestrone		Estrogen Receptor/ERR , Endogenous Metabolite
	4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.		Estrogen Receptor/ERR , Endogenous Metabolite
T12352	Oxidopamine hydrochloride	6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T12352L	Oxidopamine hydrobromide	6-Hydroxydopamine hydrobromide,6-OHDA hydrobromide	Mitophagy , Dopamine Receptor , Autophagy
	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.		Mitophagy , Dopamine Receptor , Autophagy
T6004	Tetrahydropapaverine hydrochloride	Tetrahydropapaverine HCl,Norlaudanosine HCl,Tetrahydroalkali hydrochloride	Hydroxylase
	Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.		Hydroxylase
T25384	Erbulozole	R-55104,R55104,R 55104	Microtubule Associated
	Erbulozole (R 55104) is a potent synthetic microtubule inhibitor with anti-invasive, anti-tumour and radiosensitising activity that induces Wernicke's encephalopathy-like neurotoxicity.		Microtubule Associated
T6411	Biapenem	CLI 86815,Biapenern,Omegacin,L 627,LJC 10627	Antibacterial , Antibiotic
	Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropep...		Antibacterial , Antibiotic
T15055	DB04760	MMP-13 Inhibitor	MMP
	DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.		MMP
T3570	SU4312	SU 4312,NSC 86429	VEGFR , PDGFR
	SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...		VEGFR , PDGFR
T6S1587	Notoginsenoside R2	20(S)-Notoginsenoside R2,Ginsenoside Ng-R2	Others , Nrf2
	Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and Nrf2 activation through MEK1/2-ERK1/2 pathways.		Others , Nrf2
T21470L	Davunetide acetate	Davunetide acetate(211439-12-2 Free base)	Beta Amyloid , Microtubule Associated
	Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing peptide and inhibits Aβ aggregation and Aβ-induced neurotoxicit...		Beta Amyloid , Microtubule Associated
T3385	Gypenoside XVII	GP-17,Gynosaponin S	Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
	Gypenoside XVII (Gynosaponin S) confers protection against Aβ25-35-induced neurotoxicity through estrogen receptor-dependent activation of PI3K/Akt pathways, activation of Nrf2/ARE/HO-1 and inactivation of GSK-3β pathway...		Estrogen Receptor/ERR , GSK-3 , Endogenous Metabolite
T72059	S1R agonist 2		Sigma receptor , ROS , NMDAR
	S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.		Sigma receptor , ROS , NMDAR