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SU4312

Catalog No. T3570 CAS 5812-07-7

Synonyms: NSC 86429, SU 4312

SU-4312, also known as DMBI, is a potent and selective inhibitor of <a href="/target/VEGFR" style="display: inline; color: #c13a36">VEGFR</a> and <a href="/target/PDGFR" style="display: inline; color: #c13a36">PDGFR</a> <a href="/target/Tyrosine_Kinases" style="display: inline; color: #c13a36">Tyrosine Kinases</a> (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal <a href="/target/NOS" style="display: inline; color: #c13a36">NOS</a>.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SU4312, CAS 5812-07-7

Pack Size	Availability	Price/USD
2 mg	In stock	$ 47.00
5 mg	In stock	$ 85.00
10 mg	In stock	$ 144.00
25 mg	In stock	$ 261.00
50 mg	In stock	$ 403.00
100 mg	Inquiry	$ 614.00

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Purity: 100%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
Targets&IC50	VEGFR:0.8 μM, PDGFR:19.4 μM

Synonyms	NSC 86429, SU 4312
Molecular Weight	264.328
Formula	C17H16N2O
CAS No.	5812-07-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Li Y, et al. Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation. Endocrinology. 2015 Nov;156(11):4257-68. 2. Cui W, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168(5):1201-14.

Related compound libraries

This product is contained In the following compound libraries：

Covalent Inhibitor Library Tyrosine Kinase Inhibitor Library Inhibitor Library Anti-Prostate Cancer Compound Library Kinase Inhibitor Library Anti-Colorectal Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Ovarian Cancer Compound Library Reprogramming Compound Library Cytokine Inhibitor Library

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Related compounds with same targets

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SU4312 5812-07-7 Angiogenesis Tyrosine Kinase/Adaptors PDGFR VEGFR NSC 86429 Inhibitor inhibit Vascular endothelial growth factor receptor Platelet-derived growth factor receptor SU 4312 SU-4312 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.