Home Tools

Cart

Benzamide

Catalog No. T6780 CAS 55-21-0

Synonyms: Amid kyseliny benzoove, Phenylcarboxyamide, Benzoylamide

Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Benzamide, CAS 55-21-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 30.00
100 mg	In stock	$ 43.00
200 mg	In stock	$ 61.00
500 mg	In stock	$ 98.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

Bulk Inquiry

Select Batch

Purity: 99.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Benzamide (Amid kyseliny benzoove), an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
Targets&IC50	PARP:3.3 μM
In vitro	Benzamide, an inhibitor of PARP is protective against excitatory amino acid-induced cell death in primary cultures of neurons derived from neonatal rat brain. In addition, benzamide has more recently been shown to partially prevent the loss of dopaminergic cells and the increase in reactive gliosis caused by METH in vitro in fetal rat mesencephalic cells in culture[1]. Benzamide prevents transformation in a cell cycle-specific manner, maximal prevention coinciding with early S phase, also characteristic of maximal susceptibility to transformation[2].
In vivo	PARP inhibitor benzamide is neuroprotective in C57Bl/6N mice against different types of neurotoxicities and without affecting body temperature[2]. Benzamide treatment significantly decreases the iNOS expression and number of apoptotic neurons and thereby improves the neuronal survival and memory during GCI. Benzamide administration (160 mg/kg i.p.) does not induce hypothermia and reaches the CNS in 30 min in the concentration range of 0.09-0.64 mM, at which, it shows neuroprotection[3].
Cell Research	Exposure to carcinogens and benzamide is done 10 hr after the release of the metabolically induced G1/S block and exposure lasts 10 hr, followed by three washings and refeeding with fresh media. (Only for Reference)

Synonyms	Amid kyseliny benzoove, Phenylcarboxyamide, Benzoylamide
Molecular Weight	121.14
Formula	C7H7NO
CAS No.	55-21-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 23 mg/mL (189.9 mM)

Ethanol: 23 mg/mL (189.9 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Cosi C, et al. Brain Res. 1996, 735(2):343-8. 2. Kun E, et al. Proc Natl Acad Sci U S A. 1983, 80(23):7219-23. 3. Kumaran D, et al. Behav Brain Res. 2008, 192(2):178-84. 4. Rankin PW, et al. J Biol Chem. 1989, 264(8):4312-7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tobacco Monomer Library Anti-COVID-19 Traditional Chinese Medicine Compound Library NO PAINS Compound Library Anti-Tumor Natural Product Library Human Metabolite Library Anti-Pancreatic Cancer Compound Library Food as Medicine Compound Library Anti-Aging Compound Library The Yao nationality medicine Library

Related Products

Related compounds with same targets

Tankyrase-IN-5 Rucaparib Phosphate Niraparib tosylate monohyrate Veliparib PARP7-IN-16 Isochamaejasmine PARP1-IN-14 G007-LK

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Benzamide 55-21-0 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism PARP Endogenous Metabolite Amid kyseliny benzoove neuroprotective dopamine Benzenecarboxamide Inhibitor poly ADP ribose polymerase Phenylamide neurotoxicity Phenylcarboxyamide Methamphetamine inhibit Benzoylamide inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.