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Catalog No. T6500Cas No. 347174-05-4
Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis. Ferrostatin-1 potently inhibits Erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.
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Pack SizePriceAvailabilityQuantity
5 mg$59In Stock
10 mg$89In Stock
25 mg$189In Stock
50 mg$329In Stock
200 mg$558In Stock
500 mg$897In Stock
1 mL x 10 mM (in DMSO)$65In Stock
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Product Introduction

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis. Ferrostatin-1 potently inhibits Erastin-induced ferroptosis in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and antifungal activities.
In vitro
METHODS: Human bronchial epithelial cells BEAS-2B were co-treated with LPS (10 mg/L) and Ferrostatin-1 (2 μM) for 16 h. The growth inhibition of the cells was detected by CCK-8 method.
RESULTS: Ferrostatin-1 attenuated the LPS-induced cell damage. [1]
METHODS: Human fibrosarcoma cells HT-1080 were treated with Ferrostatin-1 (0.5 μM) and Erastin (10 μM) for 4 h, and ROS levels produced by the cells were measured by Flow Cytometry.
RESULTS: Ferrostatin-1 inhibited the Erastin-induced accumulation of cytoplasmic and lipid ROS. [2]
METHODS: Mouse hippocampal neuronal cells HT-22 were treated with Ferrostatin-1 (3-12 μM) for 16 h, then treated with 5 mM glutamate for 24 h, and then LDH release was measured.
RESULTS: The release of LDH was significantly increased by treatment with glutamate, and the release of LDH was inhibited by Ferrostatin-1 treatment. [3]
In vivo
METHODS: To investigate whether ferroptosis is associated with LPS-induced acute kidney injury (AKI), Ferrostatin-1 (5 mg/kg) was administered intraperitoneally in a single dose to C57BL/6 mice, and infectious AKI was induced by intraperitoneal injection of LPS (10 mg/kg) 30 min later.
RESULTS: Ferrostatin-1 significantly protected mice from renal dysfunction and tubular injury in LPS-induced AKI. [4]
METHODS: To investigate whether iron disorders are associated with acute liver disease and its molecular mechanism, Ferrostatin-1 (2.5 μM/kg) was intraperitoneally injected into ICR mice once a day for three days, followed by intraperitoneal injection of TAA (250 mg/kg/day) for three consecutive days, to establish an acute liver injury (ALI) model in mice.
RESULTS: Ferrostatin-1 pretreatment significantly reduced TAA-induced changes in plasma ALT, AST and LDH levels, inhibited the expression of TfR1, Fpn and Ft-L proteins, and decreased iron accumulation without affecting the expression of xCT or GPX4 in the liver. Ferrostatin-1 prevents hepatic iron by decreasing death. [5]
Cell Research
Cell viability was typically assessed in 384-well format by Alamar Blue fluorescence (ex/em 530/590) measured on a Victor3 plate reader. In some experiments, Trypan Blue dye exclusion counting was performed using an automated cell counter. Cell viability under test conditions is reported as a percentage relative to the negative control treatment [1].
AliasFerrostatin 1, Ferrostatin-1 (Fer-1)
Chemical Properties
Molecular Weight262.35
Cas No.347174-05-4
Storage & Solubility Information
Storagekeep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
5% DMSO+95% Saline: 10 mg/mL (38.12 mM, precipitation)
Ethanol: 26.2 mg/mL (100 mM)
DMSO: 45 mg/mL (171.53 mM)
Solution Preparation Table
DMSO/5% DMSO+95% Saline
1 mM3.8117 mL19.0585 mL38.1170 mL190.5851 mL
5 mM0.7623 mL3.8117 mL7.6234 mL38.1170 mL
10 mM0.3812 mL1.9059 mL3.8117 mL19.0585 mL
20 mM0.1906 mL0.9529 mL1.9059 mL9.5293 mL
50 mM0.0762 mL0.3812 mL0.7623 mL3.8117 mL
100 mM0.0381 mL0.1906 mL0.3812 mL1.9059 mL


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