signalling — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7953	BpV(HOpic)	bpV (HOpic)	PTEN
	BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).		PTEN
T14327	AS1949490		Phosphatase
	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2) inhibitor, with an IC50 of 620 nM.		Phosphatase
T50103	NFAT Inhibitor-2		Others
	NFAT Inhibitor-2 is a compound used as a molecular building block.		Others
T2261	IM-12	IM 12	GSK-3
	IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.		GSK-3
T14886	Cbz-B3A		mTOR
	Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.		mTOR
T23516	VU590		Potassium Channel
	VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.		Potassium Channel
T9015	LY900009		Gamma-secretase
	LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.		Gamma-secretase
T7201	Nelociguat	BAY60-4552	Guanylate cyclase
	Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway.		Guanylate cyclase
T21890	JLK6		Gamma-secretase
	JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling		Gamma-secretase
T8200	Ginkgolide K		AMPK , Autophagy
	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.		AMPK , Autophagy
T23910	Cosalane	NSC 658586,NSC-658586,NSC 640067	HIV Protease
	Cosalane (NSC 658586) is an HIV replication inhibitor, an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice, with antiviral activity that blocks the binding of CCR7 to its natural ligands, CCL19 and ...		HIV Protease
T5S0168	Atractylenolide II	2-Atractylenolide,Asterolide	Apoptosis , ERK , p38 MAPK , Akt , STAT
	1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.		Apoptosis , ERK , p38 MAPK , Akt , STAT
T63643	BI-4142		HER
	BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.		HER
T76795	Xentuzumab	BI 836845	Akt , IGF-1R
	Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activation for the study of solid tumours.		Akt , IGF-1R
T62356	Mardepodect hydrochloride	PF-2545920 HCl,Mardepodect HCl,MP-10 HCl,PF-02545920 HCl	Apoptosis , PDE
	Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of prot...		Apoptosis , PDE
T28497	RA-839	RA 839,RA839	Nrf2
	RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxi...		Nrf2
T7511	Cyclo(his-pro)		NF-κB , Endogenous Metabolite
	Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.		NF-κB , Endogenous Metabolite
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
T77673	7-FluorotryptaMine HCl		GPR , Arrestin
	7-FluorotryptaMine HCl is a potent aromatic monoamine GPRC5A agonist that induces GPRC5A-mediated β-arrestin recruitment.7-FluorotryptaMine HCl can be used to study signalling pathways related to immunity and cancer.		GPR , Arrestin
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK