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RA-839

Catalog No. T28497 CAS 1832713-02-6

Synonyms: RA 839, RA839

RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.RA-839 inhibits the expression of inducible nitric oxide synthase and inhibits nitric oxide release.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RA-839, CAS 1832713-02-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 133.00
10 mg	In stock	$ 195.00
25 mg	In stock	$ 325.00
50 mg	In stock	$ 483.00

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Purity: 98.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	RA 839, RA839
Molecular Weight	452.57
Formula	C25H28N2O4S
CAS No.	1832713-02-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (176.77 mM), Sonication is recommended.

References and Literature

1. Winkel AF, et al. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J Biol Chem. 2015;290(47):28446-28455. 2. Winkel AF, Engel CK, Margerie D, Kannt A, Szillat H, Glombik H, Kallus C, Ruf S, Güssregen S, Riedel J, Herling AW, von Knethen A, Weigert A, Brüne B, Schmoll D. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J Biol Chem. 2015 Nov 20;290(47):28446-55. doi: 10.1074/jbc.M115.678136. Epub 2015 Oct 12. PubMed PMID: 26459563; PubMed Central PMCID: PMC4653701.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

Related Products

Related compounds with same targets

AT 14 acetate CDDO-EA Nrf2 activator-1 NSC23925 Pyridoxine hydrochloride (R)-Sulforaphane 4-Octyl itaconate CDDO-dhTFEA

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RA-839 1832713-02-6 Immunology/Inflammation Nrf2 RA 839 RA839 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.