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Cosalane

Catalog No. T23910 CAS 154212-56-3

Synonyms: NSC 658586, NSC-658586, NSC 640067

Cosalane (NSC 658586) is an HIV replication inhibitor, an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice, with antiviral activity that blocks the binding of CCR7 to its natural ligands, CCL19 and CCL21.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cosalane, CAS 154212-56-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 462.00
5 mg	In stock	$ 1,070.00
10 mg	In stock	$ 1,320.00
25 mg	In stock	$ 1,750.00
50 mg	In stock	$ 2,180.00

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Purity: 100%

ee: 99.84%

Purity: 98.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	NSC 658586, NSC-658586, NSC 640067
Molecular Weight	767.86
Formula	C45H60Cl2O6
CAS No.	154212-56-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (130.23 mM), Sonication is recommended.

References and Literature

1. Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. 2. Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091. 3. Golebiewski WM, Keyes RF, Cushman M. Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. Bioorg Med Chem. 1996 Oct;4(10):1637-48. PubMed PMID: 8931933. 4. Kuchimanchi KR, Gandhi MD, Sheta RR, Johnston TP, Santhosh KC, Cushman M, Mitra AK. Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: novel anti-HIV agents. Int J Pharm. 2002 Jan 14;231(2):197-211. PubMed PMID: 11755272.

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Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cosalane 154212-56-3 Microbiology/Virology Proteases/Proteasome HIV Protease NSC 658586 NSC-658586 NSC658586 NSC 640067 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.