resistance — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T83892	33-BCRP Inhibitor	33-Breast Cancer Resistance Protein Inhibitor
	33-BCRP inhibitor is a compound that blocks the action of breast cancer resistance protein (BCRP), enhancing the susceptibility of mitoxantrone-resistant H460/MX20 lung cancer cells to the cytotoxic effects of mitoxantro...
TQ0186	Ko 143		BCRP , ABC
	Ko 143 is a selective inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2; BCRP).		BCRP , ABC
T10815	Cinnamoylglycine		Endogenous Metabolite
	Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in humans. It is used as a potential urinary biomarker.		Endogenous Metabolite
T9982	PU23		MRP
	PU 23 is an inhibitor of multidrug-resistant protein 4 (MRP4).		MRP
T21876	DC_AC50		Apoptosis , Others
	DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducin...		Apoptosis , Others
T3881	Vaccarin		Integrin , Akt , PERK , AMPK
	Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation.		Integrin , Akt , PERK , AMPK
T4595	YHO-13177	YHO 13177,YHO13177	BCRP
	YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.		BCRP
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T3581	KS176		Potassium Channel , BCRP
	KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, showing no inhibitory activity against P-gp or MRP1.		Potassium Channel , BCRP
T3971	CASIN	Pirl1-related Compound 2	CDK , STAT , Ras
	CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).		CDK , STAT , Ras
T8157	Centhaquin	PMZ-2010,Centhaquine	Others
	Centhaquin (Centhaquine)e is an adrenergic receptor potentially for the treatment of postoperative pain and for the resuscitation of hypovolemic shock		Others
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
T1248	Sulfanitran		Antibacterial , Autophagy
	Sulfanitran is a sulfonamide antibiotic used in the poultry industry.		Antibacterial , Autophagy
T27617	Inz-1		P450
	Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the path...		P450
T12832	Amcenestrant	SAR439859	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T4628	Seladelpar	MBX 8025	PPAR
	Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.		PPAR
T6670	Silymarin	Silybin B	SARS-CoV
	Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.		SARS-CoV
T21955	GQ-16		PPAR
	GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.		PPAR
T7656	Apelin-13
	Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ...