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Silymarin

Catalog No. T6670   CAS 65666-07-1
Synonyms: Silybin B

Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.

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Silymarin Chemical Structure
Silymarin, CAS 65666-07-1
Pack Size Availability Price/USD Quantity
250 mg In stock $ 42.00
500 mg In stock $ 62.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
In vitro Mechanism of Silymarin involves different biochemical reactions, such as stimulation of the rate of ribosomal RNA synthesis by stimulating the transcription of polymerase I and ribosomal RNA genes, blockage of alpha-glycoside loops toxin intake, and protection of cell membranes from free radical-induced damage. Silymarin also displays a substantial protective effect against UVB-induced canceration at different stages, possibly through its strong antioxidant properties.
In vivo The intravenous injection LD50 of Silymarin is 391.4 mg/kg, 70.1 mg/kg, 142.3 mg/kg for mice, rats, rabbits, respectively.
Source
Synonyms Silybin B
Molecular Weight 482.44
Formula C25H22O10
CAS No. 65666-07-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (93.28 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 1 mg/mL (2.07 mM)

TargetMolReferences and Literature

1. Feher J, et al. Curr Pharm Biotechnol, 2012, 13(1), 210-217. 2. Wellington K, et al. BioDrugs, 2001, 15(7), 465-489. 3. Katiyar SK, et al. J Natl Cancer Inst, 1997, 89(8), 556-566.

Related compound libraries

This product is contained In the following compound libraries:
Flavonoid Natural Product Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Traditional Chinese Medicine Monomer Library Natural Product Library for HTS Natural Product Library Anti-Cancer Drug Library

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Keywords

Silymarin 65666-07-1 Microbiology/Virology SARS-CoV thistle angiogenesis Inhibitor Silybin B hepatocellular resistance SARS coronavirus chemopreventive inhibit HCC Milk insulin proliferation carcinoma inhibitor

 

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