Home Tools

Cart

Seladelpar

Catalog No. T4628 CAS 851528-79-5

Synonyms: MBX 8025

Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Seladelpar, CAS 851528-79-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 396.00
100 mg	In stock	$ 593.00
500 mg	In stock	$ 1,250.00
1 mL * 10 mM (in DMSO)	In stock	$ 90.00

Bulk Inquiry

Select Batch

Purity: 99.18%

Purity: 99.07%

Purity: 98.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.
Targets&IC50	PPARδ:2 nM (EC50), PPARα:1600 nM (EC50)
In vitro	Seladelpar (MBX-8025) is an orally administered, highly potent (2 nM), and selective PPAR-δ agonist, exhibiting more than 750-fold and 2500-fold specificity over PPAR-α and PPAR-γ receptors, respectively. Developed as a lipid-modifying agent, it demonstrates significant efficacy in improving insulin resistance, diabetes, and atherogenic dyslipidemia by targeting human PPAR-δ with a 50% effective concentration of 2 nM, compared to 1,600 nM for PPAR-α.
In vivo	Female Alms1 mutant (foz/foz) mice and their wild-type siblings were subjected to an atherogenic diet for 16 weeks post-weaning. Subsequently, groups (n=8-12) were randomized to receive either 10 mg/kg Seladelpar or a vehicle (1% methylcellulose) via gavage for 8 weeks. Seladelpar efficiently normalized hyperglycemia, hyperinsulinemia, and glucose disposal in foz/foz mice without significantly affecting body weight. It halved serum alanine aminotransferase levels, which ranged from 300-600 U/L in vehicle-treated foz/foz mice, and corrected serum lipid profiles as well as hepatic concentrations of free cholesterol and other lipotoxic lipids elevated in these mice compared to wild-type. These corrections led to the abolition of hepatocyte ballooning and apoptosis, marked reductions in steatosis and liver inflammation, and improved liver fibrosis. Vehicle-treated foz/foz mice had an average nonalcoholic fatty liver disease (NAFLD) activity score of 6.9, indicative of nonalcoholic steatohepatitis (NASH), which Seladelpar entirely reversed (NAFLD activity score reduced to 3.13). In wild-type mice fed an atherogenic diet, Seladelpar administration resulted in an approximate 18% reduction in body weight (P<0.05). However, it had a minimal impact on the body weight of atherogenic diet-fed foz/foz mice. These mice developed severe metabolic disruptions after 16 weeks, which Seladelpar significantly ameliorated (P<0.05). Following an intraperitoneal glucose challenge, blood glucose levels were significantly lower in Seladelpar-treated foz/foz mice compared to vehicle-treated ones (P<0.05), demonstrating Seladelpar's substantial improvement on glucose handling, an effect similarly observed in wild-type mice on an atherogenic diet (P<0.05).
Animal Research	From weaning (week 4), Alms1 mutant (foz/foz) NOD.B10 mice or Wt littermates (female mice in both groups) are fed an atherogenic diet (23% fat, 0.2% cholesterol and 45% simple carbohydrate; 4.78 kcal/g digestible energy) ad libitum for 16 weeks, after which groups are randomized (n=8-12 mice/group) to once-a-day oral administration (by gavage) for 8 weeks of Seladelpar (10 mg/kg in 1% methylcellulose) or vehicle (controls). Animals are housed under 12-hour light/dark cycle and constant temperature of 22°C and receive maximal humane care[2].

Synonyms	MBX 8025
Molecular Weight	444.46
Formula	C21H23F3O5S
CAS No.	851528-79-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (22.5 mM)

References and Literature

1. Bays HE, et al. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97. 2. Haczeyni F, et al. The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. Hepatol Commun. 2017 Jul 31;1(7):663-674.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Transcription Factor-Targeted Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Anti-Diabetic Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Human Metabolite Library

Related Products

Related compounds with same targets

(S)-(+)-Ibuprofen Methyl oleanonate Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- Ketorolac-d5 Glabridin LY518674 PPARγ agonist 8 T0070907

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Seladelpar 851528-79-5 DNA Damage/DNA Repair Metabolism PPAR MBX-8025 Peroxisome proliferator-activated receptors active atherogenic diabetes orally MBX8025 inhibit dyslipidemia resistance MBX 8025 insulin Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.