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DC_AC50

Catalog No. T21876 CAS 497061-48-0

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducing cancer cell proliferation and tumour growth.

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DC_AC50, CAS 497061-48-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 42.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 105.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 312.00
100 mg	In stock	$ 468.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 100%

Purity: 99.9%

Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

DC_AC50 synergised with carboplatin in combination treatment of human and canine OSA cells to reduce cancer cell viability.?DC_AC50-treated cells were significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis.?DC_AC50 also potentiated carboplatin-induced apoptosis in OSA cells and decreased clonogenic survival.?Finally, DC_AC50 reduced the migratory ability of OSA cells.?These results justify further investigation into inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.

Molecular Weight	424.26
Formula	C17H12BrF2N3OS
CAS No.	497061-48-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (58.93 mM)

References and Literature

1. Jordon M Inkol, et al. Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy. Vet Comp Oncol. 2020 Dec;18(4):559-569. 2. Jing Wang, et al. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Cuproptosis Compound Library Apoptosis Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compound Library

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Keywords

DC_AC50 497061-48-0 Apoptosis Others DC_AC-50 resistance osteosarcoma CCS copper chaperones Atox1 inhibit Chemotherapy Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.