neutrophils — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39437	Cevidoplenib dimesylate		Syk
	Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.		Syk
T21815	ONO-RS-082		Others
	ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.		Others
TQ0105	CAY10650		Phospholipase
	CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).		Phospholipase
T17250	W-54011		ROS , Complement System
	W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g...		ROS , Complement System
T8930	CID44216842	KUC103479N-02	CDK , Ras
	CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT...		CDK , Ras
T8531	M-3M3FBS		Apoptosis , Phospholipase
	m-3M3FBS is a phospholipase C (PLC) activator.		Apoptosis , Phospholipase
T8288	14-Deoxyandrographolide		Apoptosis , Others
	14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.		Apoptosis , Others
T1076	Dexamethasone	MK 125,Prednisolone F,NSC 34521,Hexadecadrol	Glucocorticoid Receptor , Mitophagy , IL Receptor , SARS-CoV , Antibacterial , Antibiotic , Autophagy , Complement System
	Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced...
T40446	AG-09/1		Others
	AG-09/1 is a selective and potent formyl peptide receptor 1 (FPR1) agonist that activates chemotaxis in human neutrophils.		Others
TN1933	Mitraphylline		IL Receptor , TNF , NF-κB
	Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.		IL Receptor , TNF , NF-κB
T72322	R 59-022 hydrochloride	DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor , PKC
	R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).R 59-022 hydrochloride is a DGK inhibitor (IC50:2.8 µM) that inhibits the phosphorylation of OAG to OAPA.R...		5-HT Receptor , PKC
TP1672L	N-Formyl-Met-Ala-Ser TFA(17351-32-5 free base)		Others
	N-Formyl-Met-Ala-Ser TFA is a peptide, binds to formyl peptide receptors on neutrophils.N-Formyl-Met-Ala-Ser Peptide (fMet-Ala-Ser) binds to formyl peptide receptors on neutrophils. N-Formylmethionine-containing peptides...		Others
T5S1897	Linderalactone		Apoptosis , Others , JAK
	1. Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.		Apoptosis , Others , JAK
TN6647	4-O-Cinnamoylquinic acid		Prostaglandin Receptor
	4-O-Cinnamoylquinic acid is a small molecule compound extracted from the dried fruits of Casearia grewiifolia, which has an inhibitory effect on prostaglandins and inhibits the production of superoxide anions in human ne...		Prostaglandin Receptor
TN2286	Tsugaric acid A		NO Synthase
	Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates t...		NO Synthase
T1639	Amlexanox	CHX3673,Amoxanox,AA673	IL Receptor , FGFR , Others , IκB/IKK
	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...		IL Receptor , FGFR , Others , IκB/IKK
T77638	BIRM 271		Phospholipase , LTR
	BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leu...		Phospholipase , LTR
T9878	Croconazole		Lipoxygenase , LTR
	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno...		Lipoxygenase , LTR
TN7224	2,2'-Dihydroxy chalcone		Antibacterial , Autophagy
	2,2'-Dihydroxy chalcone is a potent inhibitor of β-glucuronidase (IC50=1.6±0.2 μM) and lysozyme (IC50=1.4±0.2 μM) release from rat neutrophils stimulated with fMLP/CB.2,2'-Dihydroxy chalcone has inhibitory activity again...		Antibacterial , Autophagy
T0468	Lidocaine	Lignocaine,Alphacaine,Xylocaine	Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor
	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat...