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Mitraphylline

Catalog No. TN1933   CAS 509-80-8

Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.

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Mitraphylline Chemical Structure
Mitraphylline, CAS 509-80-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 91.00
5 mg In stock $ 219.00
10 mg In stock $ 323.00
25 mg In stock $ 546.00
50 mg In stock $ 786.00
100 mg In stock $ 1,080.00
1 mL * 10 mM (in DMSO) In stock $ 230.00
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Purity: 99.93%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.
In vitro The alkaloids of Uncaria tomentosa micropropagated plantlets and root cultures were isolated and identified by NMR and mass spectrometry. Plantlets yielded pteropodine (1), isopteropodine (2), Mitraphylline (3), isoMitraphylline (4), uncarine F (5), speciophylline (6), rhynchophylline (7) and isorhynchophylline (8). In plantlets growing under continuous light, tetracyclic alkaloids 7 and 8 decreased from 20 ± 1.8 at 2 months to 2.2 ± 0.33 mg/g dry wt at 6 months, while the pentacyclic alkaloids 1-4 increased from 7.7 ± 1.4 to 15 ± 0.05 mg/g dry wt, supporting their biogenetic conversion. Micropropagated plantlets produced four times more alkaloids (27.6 ± 3.1 mg/g dry wt) than greenhouse plants.
Source
Molecular Weight 368.43
Formula C21H24N2O4
CAS No. 509-80-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.76 mg/mL (18.35 mM), sonification is recommended.

TargetMolReferences and Literature

1. Differential alkaloid profile in Uncaria tomentosa micropropagated plantlets and root cultures.Biotechnol Lett. 2013 May;35(5):791-7.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Anti-Cancer Active Compound Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Anti-Lung Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Breast Cancer Compound Library Antidepressant Compound Library The Yao nationality medicine Library Natural Product Library for HTS

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Keywords

Mitraphylline 509-80-8 Apoptosis Immunology/Inflammation NF-Κb TNF NF-κB IL Receptor Uncaria tomentosa Inhibitor inhibit inhibitor

 

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