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Cat No. | Product Name | Synonyms | Targets |
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T40265 | PLK1-IN-2 | PLK1-IN-2 | |
PLK1-IN-2 is a PLK1 kinase inhibitor with an IC 50 value of 0.384 μM. | |||
T2704 | MLN0905 | PLK1 Inhibitor | PLK |
MLN0905 (PLK1 Inhibitor) is an effective PLK1 inhibitor(IC50=2 nM). | |||
T71718 | Plk1 PBD-IN-143 | ||
Plk1 PBD-IN-143 is a novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD). | |||
T63886 | PLK1-IN-4 | ||
PLK1-IN-4 is a potent and selective inhibitor of PLK1 (IC50<0.508 nM). PLK1-IN-4 exhibits broad anti-proliferative effects on a wide range of cancer cells. PLK1-IN-4 is able to block the cell cycle in G2/M phase and indu... | |||
T74777 | PLK1-IN-6 | ||
PLK1-IN-6, a potent and selective inhibitor of PLK1, demonstrates significant anti-proliferative activities against cancer cells with an IC50 value of 0.45 nM [1]. | |||
T81440 | PLK1-IN-7 | ||
PLK1-IN-7 (compound 30e) is a potent inhibitor exhibiting an IC50 value of 0.66 nM and demonstrates significant antiproliferative and antitumor activities [1]. | |||
T64058 | PLK1/BRD4-IN-1 | ||
PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM). It has been shown to have good anti-tumour effects in vivo. | |||
T81441 | PLK1/p38γ-IN-1 | p38 MAPK | |
PLK1/p38γ-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38γ kinases, effectively suppressing the proliferation of human hepatocellular carcinoma and hepatoblastoma cell lines in vitro [1]. | |||
T21678 | 3MB-PP1 | PLK | |
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi... | |||
T6282 | GSK461364 | GSK461364A | PLK |
GSK461364 (GSK461364A)(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3. | |||
T22700 | Cyclapolin 9 | PLK | |
Cyclapolin 9 is a selective, potent, and ATP-competitive inhibitor of polo-like kinase 1 (PLK1) with an IC50 of 500 nM, and has not shown activity against other kinases. | |||
T2634 | Ro3280 | RO 3280,Ro5203280 | PLK |
Ro3280 (Ro5203280) is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM). | |||
T2271 | SBE13 Hydrochloride | SBE 13 hydrochloride,SBE 13 HCl | Apoptosis , PLK , Autophagy |
SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3. | |||
T6247 | Onvansertib | NMS-P937,NMS-1286937 | Apoptosis , PLK |
Onvansertib (NMS-1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of NMS-P937 forPLK1 is 5000-fold higher over PLK2/PLK3. | |||
T2438 | HMN-214 | IVX-214,HMN214 | PLK |
HMN-214 (IVX-214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM. | |||
T15454 | GW843682X | GW843682 | VEGFR , PLK , CDK , PDGFR , Aurora Kinase |
GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM). | |||
T17008 | TC-S 7005 | PLK | |
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3). | |||
T6173 | BI 2536 | Apoptosis , Epigenetic Reader Domain , PLK | |
BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3. | |||
T28904 | T521 | T 521 | PLK |
T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3. | |||
T71399 | Plogosertib | CYC140 | PLK |
Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of s... | |||
T3643 | HMN-176 | PLK | |
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1). | |||
T25969 | Poloxin-2 | Poloxin2,Poloxin 2 | PLK |
Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells. | |||
T7200 | TAK-960 | PLK | |
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively. | |||
T8912 | 5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE | PLK | |
5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1. | |||
T1839 | Mps1-IN-2 | Kinesin , PLK | |
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor. | |||
T5818 | Rigosertib sodium | Rigosertib,Estybon,ON-01910 | Apoptosis , PLK , PI3K |
Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3. | |||
T16750 | Rigosertib | ON-01910 | Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src |
Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina... | |||
T6019 | Volasertib | BI 6727 | Apoptosis , PLK |
Volasertib (BI 6727) (BI-6727) is a potent inhibitor of PLK1 (IC50: 0.87 nM), inducing mitotic arrest and apoptosis. It also inhibits PLK2/PLK3 (IC50s: 5/56 nM). | |||
T6338 | PHA-680632 | PHA 680632,PHA680632 | FGFR , PLK , Aurora Kinase |
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. | |||
T2458 | CID755673 | Serine/threonin kinase | |
CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms. | |||
T6070 | (E/Z)-Rigosertib sodium | (E/Z) ON-01910 sodium | PLK |
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidativ... | |||
T6283 | Wortmannin | SL-2052,KY-12420 | ATM/ATR , DNA-PK , Serine/threonin kinase , PLK , PI3K , Antibiotic , Autophagy |
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy. | |||
T6940 | PHA-767491 hydrochloride | CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride | Apoptosis , GSK-3 , CDK |
PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK... | |||
T6077 | ZM-447439 | Apoptosis , MEK , Src , Aurora Kinase | |
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect aga... | |||
T6458 | CYC-116 | VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase | |
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ... | |||
T41163 | ZNL 02-096 | Pomalidomide-C3-adavosertib | Apoptosis , Wee1 |
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ... | |||
T10215 | AAPK-25 | Apoptosis , PLK , Aurora Kinase | |
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ... | |||
T23849 | CAP-53194 | CAP 53194,CAP53194 | |
CAP-53194 is a selective Plk1 inhibitor. | |||
T16559 | Poloxime | PLK | |
Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity. | |||
T16560 | Poloxin | PLK | |
Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM). | |||
T69496 | MCC1019 | ||
MCC1019 is a novel selective inhibitor of the Polo-box domain of Polo-like kinase 1 (PLK1). | |||
T68428 | ZK-Thiazolidinone | ||
ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosom... | |||
T28498 | Rac-CCT-250863 | ||
Rac-CCT-250863, a potent Nek2 inhibitor, exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A. | |||
T71156 | Poloxipan | ||
Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, L... | |||
T78986 | MDEG-541 | c-Myc | |
MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1]. | |||
T68463 | BI-4834 | ||
BI-4834 is a potent and selective Polo-like kinase 1 (PLK1) inhibitor. BI-4834 is also analogue (or Me-Too) of BI-2536. In vitro test shows that BI 4834 inhibits PLK1 with IC50=7.6 nm, but with higher selectivity over th... | |||
T70977 | JMN13497 | ||
JMN13497 is an precursor compound to for synthesis of scytonemin. Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is al... | |||
T71556 | MK-1496 | ||
MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apop... | |||
T70244 | JRN73958 | ||
JRN73958 is an important precursor for the synthesis of scytonemin, also called Reduced scytonemin. Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestua... | |||
T11573 | HPN-01 | Others | |
HPN-01 is a selective IKK inhibitor (pIC50s: 6.4, 7.0, and <4.8 for IKK-α, IKK-β, and IKK-ε). HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, ErbB2, EGFR, GS... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN3848 | Dihydrobaicalein | PLK | |
Dihydrobaicalein is a natural product from Scutellaria baicalensis, a PLK1 inhibitor (IC50:6.3 μM).Dihydrobaicalein inhibits VRK2 and PLK2. | |||
T70495 | Scytonemin | ||
Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and a... | |||
TL0017 | Aristolactam AIIIa | MAPK , CDK | |
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid. |
Cat No. | Product Name | Species | Expression System |
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TMPY-04376 | PLK1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.5 kDa and the accession number is P53350. | |||
TMPY-04438 | PLK1 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus Insect Cells |
PLK1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.6 kDa and the accession number is Q07832. | |||
TMPY-02714 | PRC1 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
PRC1 (protein regulator of cytokinesis 1) is a key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. It is essential for controlling the spatiotemporal formation of the... | |||
TMPY-04407 | LOK Protein, Human, Recombinant (His) | Human | E. coli |
Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a... | |||
TMPH-03764 | YAP1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor su... |