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Poloxime

Catalog No. T16559   CAS 17302-61-3

Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.

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Poloxime Chemical Structure
Poloxime, CAS 17302-61-3
Pack Size Availability Price/USD Quantity
2 mg 5 days $ 39.00
5 mg 5 days $ 62.00
10 mg 5 days $ 92.00
25 mg 5 days $ 139.00
50 mg 5 days $ 177.00
100 mg 5 days $ 297.00
1 mL * 10 mM (in DMSO) 5 days $ 68.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Poloxime is a hydrolysis product of poloxin and is a non-ATP-competitive Plk1 inhibitor. It also has moderate Plk1 inhibitory activity.
In vitro Poloxime (100 μM) suppresses phosphopeptide binding to the polo-box domain (PBD) of polo-like kinase 1 [2].
Molecular Weight 179.22
Formula C10H13NO2
CAS No. 17302-61-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (557.97 mM)

TargetMolReferences and Literature

1. Liu M, et al. Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors. Bioorg Med Chem Lett. 2015 Feb 1;25(3):431-4. 2. Yin Z, et al. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic. ACS Chem Biol. 2013 Feb 15;8(2):303-8.

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Keywords

Poloxime 17302-61-3 Cell Cycle/Checkpoint PLK inhibitor inhibit

 

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