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HMN-214

Catalog No. T2438 CAS 173529-46-9

Synonyms: HMN214, IVX-214

HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

HMN-214, CAS 173529-46-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 126.00
25 mg	In stock	$ 230.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 531.00
500 mg	In stock	$ 1,180.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 100%

Purity: 99.28%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.
Targets&IC50	PLK1:0.12 μM.
Cell Research	Cells are seeded into a 96-well microplate at a density of 3 × 103–1 × 104 cells/well. Dilutions of HMN-214 or HMN-176 are added the next day and the plate is incubated for 72 hours. The inhibition of growth is measured by the MTT assay and IC50 values are then obtained.(Only for Reference)

Synonyms	HMN214, IVX-214
Molecular Weight	424.47
Formula	C22H20N2O5S
CAS No.	173529-46-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 12 mg/mL (28.27 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Takagi M, et al. Invest New Drugs, 2003, 21(4), 387-399. 2. Tanaka H, et al. Cancer Res, 2003, 63(20), 6942-6947. 3. DiMaio MA, et al. Mol Cancer Ther, 2009, 8(3), 592-601.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Bioactive Lipid Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Cell Cycle Compound Library Clinical Compound Library Orally Active Compound Library Anti-Cancer Drug Library

Related Products

Related compounds with same targets

T521 Poloxime 7-O-Prenylscopoletin 3MB-PP1 LFM-A13 ON-01910 Wortmannin 5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

HMN-214 173529-46-9 Cell Cycle/Checkpoint PLK HMN214 IVX214 Polo-like Kinase (PLK) inhibit HMN 214 IVX-214 Inhibitor IVX 214 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.