Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 55.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 193.00 | |
50 mg | In stock | $ 363.00 | |
100 mg | In stock | $ 622.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 72.00 |
Description | ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. |
Targets&IC50 | PDGFR:18 nM(Cell-free assay) , Flt1:42 nM(Cell-free assay) , PLK1:9 nM(Cell-free assay) , Bcr-Abl:32 nM(Cell-free assay) , Src:55 nM(Cell-free assay) |
In vitro | ON01910, a small molecule inhibitor of Plk1 activity, which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis.?This compound was not ATP-competitive, but competed for the substrate binding site of the enzyme[1]. |
In vivo | In vivo, this compound did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models.?ON01910 showed strong synergy with several chemotherapeutic agents, often inducing complete regression of tumors[1]. |
Synonyms | (E/Z) ON-01910 sodium |
Molecular Weight | 473.47 |
Formula | C21H24NNaO8S |
CAS No. | 1225497-78-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 94 mg/mL (198.53 mM)
You can also refer to dose conversion for different animals. More
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(E/Z)-Rigosertib sodium 1225497-78-8 Cell Cycle/Checkpoint PLK ON01910 ON-01910 ON 01910 (E/Z) ON-01910 sodium inhibitor inhibit