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TC-S 7005

🥰Excellent
Catalog No. T17008Cas No. 1082739-92-1

TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).

TC-S 7005

TC-S 7005

🥰Excellent
Purity: 99.516%
Catalog No. T17008Cas No. 1082739-92-1
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
Pack SizePriceAvailabilityQuantity
1 mg$52In Stock
2 mg$76In Stock
5 mg$127In Stock
10 mg$198In Stock
25 mg$373In Stock
50 mg$559In Stock
100 mg$750In Stock
500 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$141In Stock
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Purity:99.516%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
Targets&IC50
PLK1:214 nM, PLK2:4 nM, PLK3:24 nM
In vitro
In human SR fibroblasts, TC-S 7005(1 μM) obviously causess myofibroblast differentiation and decrease fibroblast proliferation rates [2].
Chemical Properties
Molecular Weight359.38
FormulaC21H17N3O3
Cas No.1082739-92-1
SmilesC[C@H](Nc1cc2c(noc2cn1)-c1ccc2OCOc2c1)c1ccccc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (278.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7826 mL13.9128 mL27.8257 mL139.1285 mL
5 mM0.5565 mL2.7826 mL5.5651 mL27.8257 mL
10 mM0.2783 mL1.3913 mL2.7826 mL13.9128 mL
20 mM0.1391 mL0.6956 mL1.3913 mL6.9564 mL
50 mM0.0557 mL0.2783 mL0.5565 mL2.7826 mL
100 mM0.0278 mL0.1391 mL0.2783 mL1.3913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TC-S-7005TC-S7005TC-S 7005TCS 7005TC S 7005PLK3PLK2PLK1
Related Tags: buy TC-S 7005 | purchase TC-S 7005 | TC-S 7005 cost | order TC-S 7005 | TC-S 7005 chemical structure | TC-S 7005 in vitro | TC-S 7005 formula | TC-S 7005 molecular weight
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