Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 35.00 | |
5 mg | In stock | $ 53.00 | |
10 mg | In stock | $ 77.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 207.00 | |
100 mg | In stock | $ 369.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms. |
Targets&IC50 | PKD:182 nM |
Kinase Assay | In Vitro Radiometric PKD Kinase Assay: The radiometric kinase assay is carried out by coincubating 0.5 μCi of [γ-32P]ATP, 20 μM ATP, 50 ng of purified recombinant human PKD (PKD1, PKD2, and PKD3) or CAMKIIα proteins, and 2.5 μg of Syntide-2 in 50 μl of kinase buffer that contains 50 mM Tris-HCl, pH 7.5, 4 mM MgCl2, 10 mM β-mercaptoethanol. The reaction is carried out under conditions that the initial rate is within the linear kinetic range. The filter papers are then washed three times in 0.5% phosphoric acid, air-dried, and counted using a Beckman LS6500 multipurpose scintillation counter. |
Cell Research | Cell proliferation was determined by counting the number of viable cells upon trypan blue staining. Cell proliferation is measured by CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference) |
Molecular Weight | 217.22 |
Formula | C12H11NO3 |
CAS No. | 521937-07-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 21.7 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CID755673 521937-07-5 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase PKD Inhibitor Protein kinase D CID 755673 inhibit CID-755673 inhibitor