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CID755673

Catalog No. T2458   CAS 521937-07-5

CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.

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CID755673 Chemical Structure
CID755673, CAS 521937-07-5
Pack Size Availability Price/USD Quantity
2 mg In stock $ 35.00
5 mg In stock $ 53.00
10 mg In stock $ 77.00
25 mg In stock $ 128.00
50 mg In stock $ 207.00
100 mg In stock $ 369.00
1 mL * 10 mM (in DMSO) In stock $ 57.00
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Purity: 99.84%
Purity: 99.74%
Purity: 99.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.
Targets&IC50 PKD:182 nM
Kinase Assay In Vitro Radiometric PKD Kinase Assay: The radiometric kinase assay is carried out by coincubating 0.5 μCi of [γ-32P]ATP, 20 μM ATP, 50 ng of purified recombinant human PKD (PKD1, PKD2, and PKD3) or CAMKIIα proteins, and 2.5 μg of Syntide-2 in 50 μl of kinase buffer that contains 50 mM Tris-HCl, pH 7.5, 4 mM MgCl2, 10 mM β-mercaptoethanol. The reaction is carried out under conditions that the initial rate is within the linear kinetic range. The filter papers are then washed three times in 0.5% phosphoric acid, air-dried, and counted using a Beckman LS6500 multipurpose scintillation counter.
Cell Research Cell proliferation was determined by counting the number of viable cells upon trypan blue staining. Cell proliferation is measured by CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference)
Molecular Weight 217.22
Formula C12H11NO3
CAS No. 521937-07-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 21.7 mg/mL (100 mM)

TargetMolReferences and Literature

1. Sharlow ER, et al. J Biol Chem. 2008, 283(48), 33516-33526. 2. Yuan J, et al. Front Physiol. 2012, 3, 60. 3. Scheiter M, et al. Front Immunol. 2013, 4, 66.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Kinase Inhibitor Library Immunology/Inflammation Compound Library Autophagy Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library HIF-1 Signaling Pathway Compound Library Inhibitor Library

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Keywords

CID755673 521937-07-5 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase PKD Inhibitor Protein kinase D CID 755673 inhibit CID-755673 inhibitor

 

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