of-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2127	OF-1		Epigenetic Reader Domain
	OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.		Epigenetic Reader Domain
T7676	LSKL, Inhibitor of Thrombospondin TSP-1 acetate	LSKL, Inhibitor of Thrombospondin TSP-1	TGF-beta/Smad
	LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .		TGF-beta/Smad
T12041	MIM1	Inhibitor of Mcl-1	BCL
	MIM1 (Inhibitor of Mcl-1) is an myeloid cell factor 1 (Mcl-1) inhibitor.		BCL
T6045	Torin 1		DNA-PK , PI3K , mTOR , Autophagy
	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.		DNA-PK , PI3K , mTOR , Autophagy
T16163	MV1		Apoptosis
	MV1 is an antagonist of IAP. When combined with HaloTag ligand, MV1 causes protein knockdown of HaloTag-fused proteins.		Apoptosis
T5338	MTOR inhibitor-1		mTOR , Autophagy
	C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.		mTOR , Autophagy
TP2147	LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)		Others
	LSKL, Inhibitor of Thrombospondin (TSP-1) TFA, a latency-associated protein (LAP)-TGFβ derived tetrapeptide, is a competitive antagonist of TGF-β1.		Others
T25253	Cinnamtannin B-1	Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358	Antioxidant , COX
	Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant a...		Antioxidant , COX
T8028	Farnesyl acetate	Farnesyl Acetate (mixture of isomers)	Others
	Farnesyl acetate (Farnesyl Acetate (mixture of isomers)) is a flavouring compound identified in foods such as blueberries.		Others
T12341	P-gp inhibitor 1		Others , P-gp
	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).		Others , P-gp
T11254	F-1		ROS , ALK , ROS Kinase
	F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathwa...		ROS , ALK , ROS Kinase
T5154	C-176	C176,STING inhibitor 1	STING
	C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor		STING
T5516	DiABZI STING agonist-1 trihydrochloride		STING
	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.		STING
T9831	MKC-1	Ro-31-7453	Apoptosis , Akt , Microtubule Associated , mTOR
	MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format...		Apoptosis , Akt , Microtubule Associated , mTOR
T8328	STING agonist-1	G10	Virus Protease , STING
	STING agonist-1 (G10) is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.		Virus Protease , STING
T8649	TMBIM6 antagonist-1	BAX-inhibitor-1,BIA	mTOR
	TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor		mTOR
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T2051	SKLB4771	FLT3-IN-1,FLT3-IN-1	FLT
	SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.		FLT
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST