keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA, a latency-associated protein (LAP)-TGFβ derived tetrapeptide, is a competitive antagonist of TGF-β1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 82.00 | |
10 mg | Inquiry | $ 117.00 | |
25 mg | Inquiry | $ 232.00 | |
50 mg | Inquiry | Inquiry | |
100 mg | Inquiry | Inquiry |
Description | LSKL, Inhibitor of Thrombospondin (TSP-1) TFA, a latency-associated protein (LAP)-TGFβ derived tetrapeptide, is a competitive antagonist of TGF-β1. |
In vitro | The KTFR sequence from ADAMTS1 is responsible for the interaction with the LSKL, Inhibitor of Thrombospondin (TSP-1) (LSKL peptide) from the latent form of TGF-β, leading to its activation [2]. |
In vivo | LSKL, Inhibitor of Thrombospondin (TSP-1) (1 mg/kg; i.p.; male Sprague-Dawley rats) is protective against subarachnoid fibrosis, attenuates ventriculomegaly and effectively suppresses hydrocephalus. LSKL, Inhibitor of Thrombospondin (TSP-1) treatment inhibits TGF-β1 activity and subsequent Smad2/3 signaling [1]. LSKL, Inhibitor of Thrombospondin (TSP-1) (30 mg/kg, i.p.) successfully inhibits TGF β-Smad signal activation induced by partial hepatectomy. It successfully attenuates TGF-β-Smad signal activation by antagonizing TSP-1, but not by reducing TSP-1 protein expression. LSKL, Inhibitor of Thrombospondin (TSP-1) accelerates hepatocyte proliferation after hepatectomy [3]. |
Molecular Weight | 572.62 |
Formula | C23H43F3N6O7 |
CAS No. | TP2147 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) TP2147 Others LSKL, Inhibitor of Thrombospondin (TSP-1) LSKL, Inhibitor of Thrombospondin (TSP 1) (TFA) LSKL, Inhibitor of Thrombospondin (TSP1) (TFA) inhibitor inhibit