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diABZI STING agonist-1 trihydrochloride

Catalog No. T5516 CAS 2138299-34-8

diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.

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diABZI STING agonist-1 trihydrochloride Chemical Structure

diABZI STING agonist-1 trihydrochloride, CAS 2138299-34-8

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Purity: 95.33%

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Description	diABZI STING agonist-1 (trihydrochloride) is stimulator of interferon genes (STING) receptor agonist.
In vitro	Activation of diABZI STING agonist-1 trihydrochloride elicits a type-I interferon response that propagates interferon receptor signalling in tumour-resident dendritic cells and leads to antitumour CD8+ T cell responses in vivo.
Animal Research	To evaluate the potential therapeutic effects of systemically administered diABZI STING agonist-1 trihydrochloride, tested the efficacy of intravenously delivered diABZI STING in a syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice.?We first established the pharmacokinetic profile of STING in BALB/c mice following intravenous injection of 3 mg/kg .?STING exhibited systemic exposure with a half-life of 1.4 h and achieved systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml).?Next, we tested an intermittent dosing paradigm in which 1.5 mg/kg STING was injected intravenously on days 1, 4, and 8 in mice with approximately 100 mm^3 subcutaneous CT-26 tumours.?Treatment with STING resulted in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improved survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43.

Molecular Weight	959.32
Formula	C42H54Cl3N13O7
CAS No.	2138299-34-8

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store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (130.30 mM)

References and Literature

1. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7.

Citations

1. Cao D, Duan L, Huang B, et al.The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.Science Signaling.2023, 16(783): eadd0082.

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Keywords

diABZI STING agonist-1 trihydrochloride 2138299-34-8 Immunology/Inflammation STING inhibit diABZI STING agonist1 trihydrochloride MPYS ERIS diABZI STING agonist-1 Trihydrochloride Inhibitor MITA diABZI STING agonist-1 Stimulator of Interferon Genes TMEM173 diABZI STING agonist 1 trihydrochloride inhibitor

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