ki-7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9238	KI-7		Adenosine Receptor
	KI-7 is an adenosine A2B receptor positive allosteric modulator.		Adenosine Receptor
TQ0022	Capromorelin Tartrate	CP 424391-18	GHSR
	Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).		GHSR
T0431	Abexinostat	CRA 24781,PCI24781,PCI-24781,PCI 24781,CRA 024781	HDAC
	PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2.		HDAC
T23077L	Novokinin acetate	Novokinin acetate (358738-77-9 free base)	RAAS
	Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.		RAAS
TQ0071	Navoximod	GDC-0919,NLG-919	Indoleamine 2,3-Dioxygenase (IDO)
	Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).		Indoleamine 2,3-Dioxygenase (IDO)
T38862	Nandrolone acetate	19-Nortestosterone 17β-acetate	Others
	Nandrolone acetate (19-Nortestosterone 17β-acetate) is a competitive inhibitor of isomerase with the Ki of 7 μM for Δ5-3-ketosteroid isomerase of Pseudomonas testosreroni.		Others
T36758	CAIX Inhibitor S4	S4	Carbonic Anhydrase
	CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.		Carbonic Anhydrase
T15162	DPA-714		Others
	DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. ...		Others
TP1882L1	Orphanin FQ(1-11) acetate(178249-41-7 free base)		Opioid Receptor
	Orphanin FQ(1-11) acetate(178249-41-7 free base) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) acetate(178249-41-7 free base) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 n...		Opioid Receptor
T19913	CKI-7	CKI 7 2HCl,CKI-7 dihydrochloride,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl	ROCK , SGK , Casein Kinase , CDK , S6 Kinase
	CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1), and MSK1.		ROCK , SGK , Casein Kinase , CDK , S6 Kinase
T28531	Facinicline hydrochloride	RG3487	5-HT Receptor , AChR
	Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimot...		5-HT Receptor , AChR
T15351	FT827		DUB
	FT827 is a covalent inhibitor of selective ubiquitin-specific protease 7 (USP7) (Ki=4.2 µM, Kd=7.8 µM) targeting the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.		DUB
T77674	3-Cyano-7-hydroxycoumarin	3-Cyanoumbelliferone
	3-Cyano-7-hydroxycoumarin (3-Cyanoumbelliferone) is a macrophage inhibitor of macrophage inhibitory factor (MIF) interconjugate isomerase with a Ki of 2.9 μM. 3-Cyano-7-hydroxycoumarin belongs to the group of coumarin de...
T60109	Protein kinase inhibitor H-7	5-(2-methylpiperazine-1-sulfonyl)isoquinoline,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine	PKC
	Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein k...		PKC
T9691L	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate		Thyroid hormone receptor(THR)
	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane.		Thyroid hormone receptor(THR)
T8435	YM90K	YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-	GluR , iGluR
	YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.		GluR , iGluR
T10191L	7-Chlorokynurenic acid	7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA	GluR , NMDAR
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...		GluR , NMDAR
T16834	S26131	N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide	MT Receptor
	S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively.		MT Receptor
T5S0994	N-Methylcytisine	Caulophylline	Others , AChR
	1. N-Methylcytisine (Caulophylline)'s nicotinic receptors have high affinity (KD = 5 nM)to nAChR from squid optical ganglia. 2. N-Methylcytisine and N, N-dimethylcytisine did not displace 14C-tubocurarine at a concentrat...		Others , AChR
T3050	ML-7 hydrochloride	ML-7 HCl	Serine/threonin kinase , Myosin , YAP , PKA , PKC
	ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...		Serine/threonin kinase , Myosin , YAP , PKA , PKC