Search Result

Search Results for " fil "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TQ0318	Filanesib	ARRY-520,ARRY 520	KSP
	Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.		KSP
T77138	Ragifilimab	INCAGN-01876,INCAGN-1876,CM-701	TNF
	Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting glucocorticoid-induced TNFR-associated protein (GITR). Ragifilimab can be used in the study of advanced or metastatic solid tumors.		TNF
T16079	Mirodenafil	SK3530	PDE
	Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.		PDE
T14982	Clofilium tosylate		Potassium Channel
	Clofilium tosylate is a potassium channel blocker. It induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3.		Potassium Channel
T9172	Simufilam dihydrochloride	PTI-125 dihydrochloride	Others
	Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds a...		Others
T1795	Carfilzomib	PR-171	Apoptosis , Proteasome , Autophagy
	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma.		Apoptosis , Proteasome , Autophagy
T27122	Dasantafil	SCH446132,SCH-446132,SCH 446132	PDE
	Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.		PDE
T15381	Gisadenafil	UK-369003	PDE
	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.		PDE
T60773	Butofilolol		Adrenergic Receptor
	Butofilolol is a novel beta-blocker with antihypertensive activity and can be used to study hypertension.		Adrenergic Receptor
T8919	Homo Sildenafil		PDE
	Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.		PDE
T9773	Thioquinapiperifil dihydrochloride	KF-31327	PDE
	Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation.		PDE
T78216	Cis-ent-Tadalafil	(6S,12aR)-Tadalafil,Tadalafil, (6S,12aR)-,cis-ent-IC-351	Others
	cis-ent-Tadalafil (cis-ent-IC-351) is a potent and selective PDE5 inhibitor that lowers blood pressure. cis-ent-Tadalafil is a potent and selective PDE5 inhibitor that reduces blood pressure.		Others
T7542	Amino Tadalafil		PDE
	Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.		PDE
T8536	Filastatin		Antifungal
	Filastatin is a long-lasting inhibitor of Candida albicans filamentation, and has potent antifungal effect.		Antifungal
T36061	N-Desmethyl Sildenafil	Desmethylsildenafil,UK-103,320	Drug Metabolite
	N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).		Drug Metabolite
T6147	Nortadalafil	Demethyl Tadalafil	PDE
	Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.		PDE
T7346	Lodenafil	Hydroxyhomosildenafil	PDE
	Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)		PDE
T0096	Vardenafil	Vivanza,Levitra,Vardenafil hydrochloride	PDE
	Vardenafil (Vivanza) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemod...		PDE
TQ0126	Mirodenafil dihydrochloride	SK-3530 dihydrochloride	PDE
	Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.		PDE
T4097	Vardenafil hydrochloride trihydrate	Vardenafil HCl Trihydrate,BAY38-9456	PDE
	Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.		PDE
T6983	Sildenafil Mesylate		PDE
	Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.		PDE
T15282	Filibuvir	PF-00868554	HCV Protease , DNA/RNA Synthesis
	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.		HCV Protease , DNA/RNA Synthesis
T8405	Vardenafil hydrochloride		PDE
	Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes		PDE
T2334	Avanafil	TA1790	PDE
	Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.		PDE
T31792	Filaminast	UNII-CDD69JC61J,Way-pda-641,WAY-PDA 641,CDD69JC61J	PDE
	Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.		PDE
T68088	Iodofiltic acid
	Iodofiltic acid can be used in the adjuvant treatment of acute coronary syndromes (Zeus ACS) and can be imaged to detect myocardial ischemia.
T16096	Filorexant	MK-6096	OX Receptor
	Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).		OX Receptor
T0467	Sildenafil citrate	UK-92480 citrate	Apoptosis , PDE , Autophagy
	Sildenafil citrate (UK-92480 citrate) , a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erectile dysfunction and less commonly for pulmonary hypertensio...		Apoptosis , PDE , Autophagy
T1398	Tadalafil	Cialis,IC-351	Apoptosis , PDE
	Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGM...		Apoptosis , PDE
T10676	Carbodenafil		PDE
	Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).		PDE
T1929	Filgotinib	GLPG0634	Tyrosine Kinases , JAK
	Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.		Tyrosine Kinases , JAK
T71519	Chlorodenafil
	Chlorodenafil is a related compound of Sildenafil -- a phosphodiesterase inhibitor.
T37181	Avanafil metabolite M4	Avanafil metabolite M4
	Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanaf...
T10373	(R)-Filanesib	(R)-ARRY-520	Others
	(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).		Others
T70630	Dichlorodenafil
	Dichlorodenafil is an inhibitor of phosphodiesterase type 5 enzyme (PDE-5).
T77181	Revdofilimab
	Revdofilimab (ABBV-368) is a human IgG1 monoclonal antibody that functions as an agonist against OX40, a member of the TNF receptor superfamily. OX40 is expressed on activated and memory T cell subsets as well as T regul...
T18320	MC-Val-Cit-PAB-carfilzomib iodide	MC-Val-Cit-PAB-carfilzomib	Others
	MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB.		Others
T77109	Omfiloctocog alfa
	Omfiloctocog alfa (SCT-800), a recombinant factor VIII (FVIII), is an essential protein for blood coagulation and a critical element of the fluid phase blood coagulation system. It is utilized in the research of Hemophil...
T68665	Yonkenafil	Tunodafil
	Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, effectively reduces cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. It potentially enhances cognitive fu...
T82475	Emfilermin
	Emfilermin, a recombinant human leukemia inhibitory factor (LIF), is utilized in the research of chemotherapy-induced peripheral neuropathy [1].
T70795	Hydroxychlorodenafil
	Hydroxychlorodenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil.
T25418	Filanesib TFA	Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA
	Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, in...
T36444	Sildenafil Chlorosulfonyl
	Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil .1It is also a potential impurity found in commercial preparations of sildenafil. 1.Nagaraju, ...
T35714	N-Desethyl Vardenafil
	N-Desethyl vardenafil is a metabolite of vardenafil , a phosphodiesterase 5 inhibitor, that is formed by the action of cytochrome P450 (CYP)3A4 and CYP3A5.
T126476	Moellendorffilin
	Moellendorffilin is a useful organic compound for research related to life sciences and the catalog number is T126476.
T78329	Litifilimab	BIIB059
	Litifilimab, a humanized IgG1-κ antibody, targets the C-type lectin domain family 4 member C (CLEC4C) and has potential applications in the study of cutaneous lupus erythematosus (CLE) [1] [2].
T26273	Thioquinapiperifil	KF-31327,KF 31327,KF-31327 free base,KF31327
	Thioquinapiperifil is a type of phosphodiesterase-5 (PDE-5) inhibitor found in dietary supplements.
T25513	Hydroxythiohomosildenafil	Sulfohydroxyhomosildenafil,Hydroxyhomosildenafil thione
	Hydroxythiohomosildenafil, an analogue of sildenafil, is a phosphodiesterase-5 (PDE-5) inhibitor.
T70472	Filgotinib HCl hydrate
	Filgotinib hydrochloride hydrate is a potent and selective JAK1 inhibitor under investigation for the treatment of rheumatoid arthritis (RA) and Crohn's disease.
T9569	Simufilamum
	Simufilam (PTI-125) is a low toxicity, orally active filamin A ( FLNA ) activator. Simufilam preferentially binds altered FLNA and restores its native conformation, restores receptor and synaptic activities, reduces its ...

Compounds

Filanesib

TQ0318

Synonym: ARRY-520,ARRY 520

Target: KSP

Ragifilimab

T77138

Synonym: INCAGN-01876,INCAGN-1876,CM-701

Target: Potassium Channel

Simufilam dihydrochloride

T9172

Synonym: PTI-125 dihydrochloride

Target: Apoptosis, Proteasome, Autophagy

Dasantafil

T27122

Synonym: SCH446132,SCH-446132,SCH 446132

Target: Adrenergic Receptor

Thioquinapiperifil dihydrochloride

Synonym: (6S,12aR)-Tadalafil,Tadalafil, (6S,12aR)-,cis-ent-IC-351

N-Desmethyl Sildenafil

T36061

Synonym: Desmethylsildenafil,UK-103,320

Target: Drug Metabolite

Nortadalafil

T6147

Synonym: Demethyl Tadalafil

Target: PDE

Lodenafil

T7346

Synonym: Hydroxyhomosildenafil

Target: PDE

Vardenafil

T0096

Synonym: Vivanza,Levitra,Vardenafil hydrochloride

Target: PDE

Mirodenafil dihydrochloride

TQ0126

Synonym: SK-3530 dihydrochloride

Target: PDE

Vardenafil hydrochloride trihydrate

T4097

Synonym: Vardenafil HCl Trihydrate,BAY38-9456

Target: HCV Protease, DNA/RNA Synthesis

Vardenafil hydrochloride

Synonym: UNII-CDD69JC61J,Way-pda-641,WAY-PDA 641,CDD69JC61J

Synonym: UK-92480 citrate

Target: Apoptosis, PDE, Autophagy

Tadalafil

T1398

Synonym: Cialis,IC-351

Target: Apoptosis, PDE

Target: Tyrosine Kinases, JAK

Avanafil metabolite M4

T37181

Synonym: Avanafil metabolite M4

Target:

(R)-Filanesib

T10373

Synonym: (R)-ARRY-520

MC-Val-Cit-PAB-carfilzomib iodide

T18320

Synonym: MC-Val-Cit-PAB-carfilzomib

Synonym: Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA

Target:

Sildenafil Chlorosulfonyl

T36444

Synonym:

Target:

N-Desethyl Vardenafil

Synonym: KF-31327,KF 31327,KF-31327 free base,KF31327

Target:

Hydroxythiohomosildenafil

T25513

Synonym: Sulfohydroxyhomosildenafil,Hydroxyhomosildenafil thione

Target:

Filgotinib HCl hydrate

Cat No.	Product Name	Synonyms	Targets
T17199	Udenafil		PDE
	Udenafil is an inhibitor of PDE5 .		PDE
T6740	Bafilomycin A1		Apoptosis , Proton pump , Antibacterial , Antibiotic , Autophagy
	Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autopha...
T11287	Filipin complex		Antifungal
	Filipin complex is a 28-membered cyclopentene macrolide antifungal antibiotic produced by a mixture of S. filipinensis, S. avermitilis, and S. miharaensis that inhibits the entry of PRRSV viruses into cells.		Antifungal
T1121	Podofilox	Podophyllotoxin,(+)-Shikonin	Microtubule Associated , Topoisomerase
	Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irrit...		Microtubule Associated , Topoisomerase
TN4057	Filic-3-en-25-al		Others
	Filic-3-en-25-al is a natural product for research related to life sciences. The catalog number is TN4057 and the CAS number is 147850-78-0.		Others
TN1066	Filixic acid ABA		Influenza Virus
	Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.		Influenza Virus
T22598	Bafilomycin C1		Others
	vacuolar H+-ATPases (V-ATPases) inhibitor		Others
T10455	Bafilomycin B1		Others
	Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi.		Others
TN5965	Filicane-3β,4α,25-triol	3β,4α,25-Trihydroxyfilicane
	Filicane-3β,4α,25-triol is a natural product for research related to life sciences. The catalog number is TN5965 and the CAS number is 2361548-00-5.
T11288	Filipin III		Antifungal
	Filipin III is extracted from strain KPE18H and has significant antifungal activity.		Antifungal
TN4058	Filicenol B		Others
	Filicenol B is a natural product from Adiantum lunulatum.		Others
T30170	Aspafilioside A
	Aspafilioside A is a steroidal saponin isolated from the root of Asparagus filicinus.
TN3606	Cassyfiline		Others
	Cassyfiline and actinodaphnine show high activity against Mel-5 (IC 50 : 24.3 microM and 25.7 microM, respectively) and HL-60 (IC 50 : 19.9 microM and 15.4 microM, respectively).		Others

Natural Products

Target: Apoptosis, Proton pump, Antibacterial, Antibiotic, Autophagy

Synonym: Podophyllotoxin,(+)-Shikonin

Target: Microtubule Associated, Topoisomerase

Target: Influenza Virus

Filicane-3β,4α,25-triol

TN5965

Synonym: 3β,4α,25-Trihydroxyfilicane

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02879	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)	Human	E. coli
	Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways a...
TMPY-02818	IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)	Human	E. coli
	Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways a...
TMPY-02458	IL-1F8 Protein, Human, Recombinant	Human	E. coli
	Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines inclu...
TMPY-02817	IL-1F8 Protein, Human, Recombinant (His)	Human	E. coli
	Interleukin-1 family member 8(IL1F8) also known as IL36B, is a member of the interleukin 1(IL-1) cytokine family. IL1F8 may contain a 12-stranded beta-trefoil structure. Until recently, the IL-1 family of cytokines inclu...
TMPY-01956	IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways a...
TMPY-02597	IL-37 Protein, Human, Recombinant	Human	E. coli
	Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the e...
TMPY-00847	IL-36RN/IL-1F5 Protein, Human, Recombinant	Human	E. coli
	Interleukin-1 family member 5 (IL-1F5), also known as interleukin 36 receptor antagonist (IL36RA), is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-ka...
TMPH-03637	Profilin Protein, Toxoplasma gondii, Recombinant (E. coli, His)	Toxoplasma gondii	E. coli
	Profilin Protein, Toxoplasma gondii, Recombinant (E. coli, His) is expressed in E. coli.
TMPH-03334	Mitofilin Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	Mitofilin Protein, Rat, Recombinant (His) is expressed in in vitro E. coli expression system.
TMPH-01343	FILIP1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.
TMPY-03607	Cofilin Protein, Human, Recombinant (His)	Human	E. coli
	CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments t...
TMPH-01910	Profilin-1 Protein, Human, Recombinant (GST)	Human	E. coli
	Profilin-1 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-01341	FILIP1L Protein, Human, Recombinant (His)	Human	E. coli
	Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma gr...
TMPH-00478	DIT33 Protein, Dirofilaria immitis, Recombinant (His & Myc)	Dirofilaria immitis	E. coli
	DIT33 Protein, Dirofilaria immitis, Recombinant (His & Myc) is expressed in E. coli.
TMPY-03657	Profilin 2 Protein, Human, Recombinant (His)	Human	E. coli
	Profilin 2, also known as PFN2, is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and l...
TMPY-03990	Profilin 4 Protein, Human, Recombinant (His)	Human	E. coli
	PFN4, also known as profilin 4, is a member of the profilin family. Profilin can be detected in all eukaryotic organisms. It plays an important role in the spatially and temporally controlled growth of actin microfilamen...
TMPJ-00943	Profilin 2 Protein, Human, Recombinant	Human	E. coli
	Profilin-II (PFN2) is ubiquitous protein which belongs to the profilin family. PFN2 binds to actin, thenaffects the structure of the cytoskeleton. At high concentrations, profiling prevents the polymerization of actin, w...
TMPH-03096	Profilin 2 Protein, Phleum pratense, Recombinant (His & Myc)	Phleum pratense	E. coli
	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the forma...
TMPH-03638	Profilin Protein, Toxoplasma gondii, Recombinant (His)	Toxoplasma gondii	Yeast
	Profilin Protein, Toxoplasma gondii, Recombinant (His) is expressed in Yeast.
TMPH-01340	Filaggrin Protein, Human, Recombinant (His)	Human	Yeast
	Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
TMPH-01342	Filamin-A Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplas...
TMPY-02499	Cofilin 2 Protein, Human, Recombinant (His)	Human	E. coli
	Cofilin 2 (muscle), also known as CFL2, is a member of cofilin family of the actin-binding protein superfamily. Cofilin2 shows significant homology to the other two members: cofilin 1 and DSTN, through its entire sequenc...