Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
Description | Tadalafil is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. |
Targets&IC50 | PDE5:1.8 nM |
Synonyms | Cialis, IC-351 |
Molecular Weight | 389.4 |
Formula | C22H19N3O4 |
CAS No. | 171596-29-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 38.9 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Tadalafil 171596-29-5 Apoptosis Metabolism PDE Cialis IC-351 IC351 IC 351 Inhibitor inhibit Phosphodiesterase (PDE) inhibitor