store at low temperature
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces apoptosis.Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.
Description | Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces apoptosis.Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. |
In vitro | Bafilomycin A1 at a concentration of 1 nM effectively and specifically kills pediatric B-cell acute lymphoblastic leukemia cells. Bafilomycin A1 induces the binding of Beclin 1 to Bcl-2, which further inhibits autophagy and promotes apoptotic cell death[1]. The growth of the BEL-7402 hepatocellular carcinoma and HO-8910 ovarian cancer cell lines are retarded and the metastatic potential is inhibited by Bafilomycin A1. Transmission electron microscopy and assays of capsase-3 and -9 suggest that Bafilomycin A1 induces apoptosis[2]. Bafilomycin A1 inhibits the growth of a variety of cultured cells dose-dependently, including golden hamster embryo, NIH-3T3 fibroblasts, PC12 and HeLa cells. The IC50 of Bafilomycin A1 for inhibition of cell growth ranges from 10 to 50 nM[3]. |
In vivo | Chronic treatment with Bafilomycin A1 at the dose of 1 mg/kg significantly inhibits the tumor growth compared with controls, after 21 days[4]. |
Molecular Weight | 622.84 |
Formula | C35H58O9 |
CAS No. | 88899-55-2 |
store at low temperature
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 99 mg/mL(158.95 mM)
H2O: 0.1 mg/mL (0.16 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Bafilomycin A1 88899-55-2 Apoptosis Autophagy Membrane transporter/Ion channel Microbiology/Virology Antibiotic Antibacterial Proton pump Proton Pump Bafilomycin A 1 Bafilomycin A-1 BafA1 BafA 1 inhibit BafA-1 Inhibitor Bacterial inhibitor