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Autophagy Autophagy Bafilomycin A1

Bafilomycin A1

Catalog No. T6740   CAS 88899-55-2

Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces apoptosis.Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.

Bafilomycin A1, CAS 88899-55-2
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1 mg In stock 382.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bafilomycin A1 induces caspase-independent cell death in hepatocellular carcinoma cells via targeting of autophagy and MAPK pathways. Bafilomycin A1 is a vacuolar H+-ATPase inhibitor (IC50: 0.44 nM). It is also found to inhibit autophagy while induces apoptosis.Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.
Targets&IC50 Antibacterial,  
In vitro Bafilomycin A1 at a concentration of 1 nM effectively and specifically kills pediatric B-cell acute lymphoblastic leukemia cells. Bafilomycin A1 induces the binding of Beclin 1 to Bcl-2, which further inhibits autophagy and promotes apoptotic cell death[1]. The growth of the BEL-7402 hepatocellular carcinoma and HO-8910 ovarian cancer cell lines are retarded and the metastatic potential is inhibited by Bafilomycin A1. Transmission electron microscopy and assays of capsase-3 and -9 suggest that Bafilomycin A1 induces apoptosis[2]. Bafilomycin A1 inhibits the growth of a variety of cultured cells dose-dependently, including golden hamster embryo, NIH-3T3 fibroblasts, PC12 and HeLa cells. The IC50 of Bafilomycin A1 for inhibition of cell growth ranges from 10 to 50 nM[3].
In vivo Chronic treatment with Bafilomycin A1 at the dose of 1 mg/kg significantly inhibits the tumor growth compared with controls, after 21 days[4].
Molecular Weight 622.84
Formula C35H58O9
CAS No. 88899-55-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 99 mg/mL(158.95 mM)

DMSO: 0.1 mg/mL (0.16 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. al-Fifi ZI, et al. Insect BiochemMol Biol, 1998, 28(4), 201-211. 2. Du L, Wu Y, Han X, et al. NICE‑3‑knockdown induces cell cycle arrest and autophagy in lung adenocarcinoma cells via the AKT/mTORC1 signaling pathway[J]. Experimental and Therapeutic Medicine . 2021, 21(6): 1-8.

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