Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 437.00 | |
10 mg | In stock | $ 646.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,380.00 | |
100 mg | In stock | $ 1,860.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 547.00 |
Description | Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP. |
Targets&IC50 | PDE1A:9.1 μM, PDE5A:3.6 nM |
In vitro | In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2]. |
In vivo | In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2]. |
Synonyms | UK-369003 |
Molecular Weight | 519.62 |
Formula | C23H33N7O5S |
CAS No. | 334826-98-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (105.85 mM)
You can also refer to dose conversion for different animals. More
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Gisadenafil 334826-98-1 Metabolism PDE Inhibitor UK-369003 inhibit Phosphodiesterase (PDE) UK 369003 UK369003 inhibitor