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Vardenafil

Catalog No. T0096 CAS 224785-90-4

Synonyms: Vardenafil hydrochloride, Vivanza, Levitra

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme Guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.

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Vardenafil, CAS 224785-90-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP.

Targets&IC50

PDE5:0.7 nM

Synonyms	Vardenafil hydrochloride, Vivanza, Levitra
Molecular Weight	488.6
Formula	C23H32N6O4S
CAS No.	224785-90-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 22.5 mg/mL (46.05 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Saenz de Tejada I, et al. Int J Impot Res, 2001, 13(5), 282-290.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Vardenafil 224785-90-4 Metabolism PDE Phosphodiesterase (PDE) erectile dysfunction stimulation diabetes Zucker diabetic fatty (ZDF) rats smooth Vardenafil hydrochloride hepatitis muscle inhibit impotence erectile Inhibitor pharmacokinetics Endogenous Metabolite dysfunction cGMP Vivanza Levitra selective inhibitor

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