Search Result

Search Results for " caspase-8 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T7019	Z-IETD-FMK	Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor	Caspase
	Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.		Caspase
T10384	Farudodstat	ASLAN003	Apoptosis , Dehydrogenase , DNA/RNA Synthesis
	Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-class candidate in AML.		Apoptosis , Dehydrogenase , DNA/RNA Synthesis
T76571	Caspase-8-IN-1
	Caspase-8-IN-1 is a potent caspase-8 inhibitor [1] .
T2065	Bioymifi	DR5 Activator	Apoptosis , TNF
	Bioymifi (DR5 Activator) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells.		Apoptosis , TNF
T6761	Ossirene	AS101	IL Receptor , Caspase , Interleukin
	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.		IL Receptor , Caspase , Interleukin
T6005	Z-DEVD-FMK	Caspase-3 Inhibitor	Caspase
	Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.		Caspase
T10366L	Arg-Gly-Asp-Ser acetate	Arg-Gly-Asp-Ser acetate(91037-65-9 free base)	Integrin
	Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin ...		Integrin
T36333	Z-IETD-AFC
	Z-IETD-AFC is a fluorescent substrate for caspase-8 and granzyme B. It can be used to quantify cysteinyl aspartate-8 or granzyme B activity.
T36343	Ac-LETD-AFC
	Ac-LETD-AFC is a fluorescent substrate specifically cleaved by caspase-8 and can be used to quantify caspase activity by fluorescence detection of free AFC.Ac-LETD-AFC has an excitation wavelength of 400 nm and an emissi...
T30077	Anisperimus	LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195	Caspase
	Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level, and prevents CNS autoimmunity by promoting the developmen...		Caspase
T39308	Boc-Asp(OMe)-fluoromethyl ketone	Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK	Caspase
	Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) is a broad range caspase inhibitor. Boc-Asp(OME)-Fluoromethyl Ketone inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemot...		Caspase
T9083	TC11	CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11	BCL , Caspase , CDK
	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.		BCL , Caspase , CDK
TQ0146	Ac-DEVD-CHO		Apoptosis , Caspase
	Ac-DEVD-CHO is a specific Caspase-3 inhibitor (Ki: 230 pM).Ac-DEVD-CHO has an inhibitory effect in SLNT-induced apoptosis.		Apoptosis , Caspase
T0282	Q-VD-OPH	Quinoline-Val-Asp-Difluorophenoxymethylketone	Caspase , HIV Protease
	Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a pan-caspase inhibitor with potent antiapoptotic properties.		Caspase , HIV Protease
T80093	IETD-CHO TFA		Caspase
	IETD-CHO TFA (Caspase-8-IN-1) functions as a potent inhibitor of caspase-8 [1].		Caspase
T21293	MX1013	MX 1013,MX-1013
	MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.
T83181	Ac-IETD-AMC
	Ac-IETD-AMC, a fluorogenic substrate specific for caspase-8 and granzyme B with an acetyl (Ac) moiety, is commonly utilized to quantify caspase-8 activity [1].
T23859	CaspPro	C-2,C 2,Casp-Pro,Casp Pro,C2
	CaspPro is a selective activator of caspase 8 that acts by potentiating TRAIL-induced cell death.
T73870	Arg-Gly-Asp-Ser TFA
	Arg-Gly-Asp-Ser (TFA) is an integrin-binding sequence that serves to inhibit integrin receptor function by directly and specifically binding to pro-caspase-8, pro-caspase-9, and pro-caspase-3, without interacting with pr...
T72435	Z-LE(OMe)TD(OMe)-FMK
	Z-LE(OMe)TD(OMe)-FMK is a selective inhibitor of caspase-8, effectively inhibiting cellular apoptosis.
T80467	Boc-AEVD-CHO		Caspase
	Boc-AEVD-CHO, a selective Caspase 8 inhibitor, facilitates apoptosis research and the investigation of immune and inflammatory diseases [1] [2].		Caspase
T39672	Ac-Ile-Glu-Thr-Asp-pNA
	Ac-Ile-Glu-Thr-Asp-pNA is a caspase-8 substrate that undergoes enzymatic binding and cleavage specifically at the Ile-Glu-Thr-Asp (IETD) peptide sequence. This cleavage results in the release of p-nitroalinide, which can...
T19906	5'-O-Tritylthymidine	M-13,M13,M 13,Monotritylthymidine
	5'-O-Tritylthymidine is a blocker of the formation of the FAK/Mdm-2 complex. 5'-O-Tritylthymidine activates p53 and caspase-8. It also leads to increase detachment and apoptosis in breast and colon cancers.
T41189	AY 254
	AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-woun...
T78586L	Ac-IETD-CHO TFA	Ac-IETD-CHO TFA（191338-86-0 Free base )	Apoptosis , Caspase
	Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-mediated apoptosis.		Apoptosis , Caspase
T78586	Ac-IETD-CHO		Apoptosis
	Ac-IETD-CHO is a potent, reversible inhibitor of granzyme B and caspase 8, which also impedes Fas-mediated apoptosis, hemorrhagic conditions, and liver failure. Furthermore, this compound hampers cell death induced by cy...		Apoptosis
T76300	Edratide
	Edratide (TV 4710), a 19-amino-acid synthetic peptide derived from the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that exhibits the 16/6 Id idiotype, has been found to lower apoptosis rates ...
T35729	Nemadipine-A
	Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in...
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42)), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from the alpha- and gamma-secretase cleavage of amyloid precursor protei...
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and t...
T78855	Anticancer agent 157		NO Synthase
	Anticancer Agent 157 (compound 15) is a nitric oxide (NO) inhibitor with IC50 values of 0.62 μg/mL, exhibiting both anti-inflammatory and anticancer effects. It interacts with inducible NO synthase (iNOS) and caspase 8, ...		NO Synthase
T72475	Anticancer agent 58
	Anticancer agent 58 exhibits inhibitory activity against various cancer cell lines, particularly A549 and T24, with IC50 values of 0.6 μM and 0.7 μM, respectively. It promotes apoptosis through the activation of caspase ...
T11864	Iptacopan	LNP023	Others
	Iptacopan (LNP023) is an inhibitor with high affinity for factor B.		Others

Compounds

Z-IETD-FMK

T7019

Synonym: Z-IE(OMe)TD(OMe)-FMK,Caspase-8 Inhibitor

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis

Synonym: DR5 Activator

Target: Apoptosis, TNF

Ossirene

T6761

Synonym: AS101

Target: IL Receptor, Caspase, Interleukin

Z-DEVD-FMK

T6005

Synonym: Caspase-3 Inhibitor

Target: Caspase

Arg-Gly-Asp-Ser acetate

T10366L

Synonym: Arg-Gly-Asp-Ser acetate(91037-65-9 free base)

Synonym: LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195

Target: Caspase

Boc-Asp(OMe)-fluoromethyl ketone

T39308

Synonym: Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK

Target: Caspase

TC11

T9083

Synonym: CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

Target: BCL, Caspase, CDK

Ac-DEVD-CHO

TQ0146

Synonym:

Target: Apoptosis, Caspase

Q-VD-OPH

T0282

Synonym: Quinoline-Val-Asp-Difluorophenoxymethylketone

Target: Caspase, HIV Protease

Synonym: MX 1013,MX-1013

Synonym: C-2,C 2,Casp-Pro,Casp Pro,C2

Ac-Ile-Glu-Thr-Asp-pNA

Synonym: M-13,M13,M 13,Monotritylthymidine

Synonym: Ac-IETD-CHO TFA（191338-86-0 Free base )

Target: Apoptosis, Caspase

Cat No.	Product Name	Synonyms	Targets
TN2215	Taurochenodeoxycholic acid sodium	Sodium taurochenodeoxycholate	Apoptosis , Endogenous Metabolite
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and...		Apoptosis , Endogenous Metabolite
T2163	Dihydrocapsaicin	CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others , TRP/TRPV Channel
	Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an...		Others , TRP/TRPV Channel
T9503	PHYTOSPHINGOSINE		Apoptosis
	Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.		Apoptosis
T13815	Penicillic acid		Apoptosis , Caspase , Antibacterial , Antibiotic
	Penicillic acid, a polyketide mycotoxin, synthesized by various species of Aspergillus and Penicillium, acts as an inhibitor of Fas ligand-induced apoptosis by impeding self-processing of caspase-8. Additionally, in vitr...		Apoptosis , Caspase , Antibacterial , Antibiotic
T2959	Ginsenoside Rh2	20(S)-Rh2,20S-Ginsenoside Rh2,20(S)-Ginsenoside Rh2	Apoptosis , EGFR , Caspase , Endogenous Metabolite
	Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.		Apoptosis , EGFR , Caspase , Endogenous Metabolite
T3240	Citronellol	dihydrogeraniol,(±)-β-Citronellol	Reactive Oxygen Species
	Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.		Reactive Oxygen Species
T5S1632	Barlerin	8-O-Acetylshanzhiside methyl ester,ND01	VEGFR , TNF , NF-κB , Akt , Caspase
	Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...		VEGFR , TNF , NF-κB , Akt , Caspase
T10990	Dehydrocorydaline chloride	13-Methylpalmatine chloride	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T6S0721	Orientin	Lutexin,Luteolin-8-glucoside	Others
	1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...		Others
T2S2362	Dehydrocorydaline nitrate		BCL , Others , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect of Corydalis Tuber on allergic reactions may be partially a...
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
TMA0918	Neochamaejasmine A		Caspase
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating...		Caspase
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce...

Natural Products

Taurochenodeoxycholic acid sodium

TN2215

Synonym: Sodium taurochenodeoxycholate

Target: Apoptosis, Endogenous Metabolite

Dihydrocapsaicin

T2163

Synonym: CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Target: Apoptosis, Caspase, Antibacterial, Antibiotic

Ginsenoside Rh2

T2959

Synonym: 20(S)-Rh2,20S-Ginsenoside Rh2,20(S)-Ginsenoside Rh2

Target: Apoptosis, EGFR, Caspase, Endogenous Metabolite

Citronellol

T3240

Synonym: dihydrogeraniol,(±)-β-Citronellol

Target: Reactive Oxygen Species

Barlerin

T5S1632

Synonym: 8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Dehydrocorydaline chloride

T10990

Synonym: 13-Methylpalmatine chloride

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Orientin

T6S0721

Synonym: Lutexin,Luteolin-8-glucoside

Target: Others

Dehydrocorydaline nitrate

T2S2362

Synonym:

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline

T5S2358

Synonym: Dehydrocorydalin,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01057	Caspase-8 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase-8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is Q14790.
TMPH-01315	CASR Protein, Human, Recombinant (GST)	Human	E. coli
	CASR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 93.6 kDa and the accession number is P41180.
TMPJ-01256	Caspase-10 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granz...
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter mol...
TMPJ-00697	NOL3 Protein, Human, Recombinant (GST)	Human	E. coli
	Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...
TMPJ-00215	Fas/CD95 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected...
TMPY-02831	Caspase-7 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis, necrosis and inflammation. There are tw...
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting d...
TMPY-02213	RAIDD Protein, Human, Recombinant (His)	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissu...
TMPJ-00696	NOL3 Protein, Human, Recombinant	Human	E. coli
	Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in...
TMPY-04123	CEACAM1 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 71.4 kDa and the accession number is P13688-8.
TMPY-01176	CIAP1 Protein, Human, Recombinant (Avi)	Human	E. coli
	The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP r...
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His)	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPJ-00828	Tau-F Protein, Human, Recombinant	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons...
TMPJ-00808	CD45RA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8.
TMPJ-01330	CD299 Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	CD299 is also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligermerization. Multiple human DC-S...
TMPH-01705	Mucin-1/MUC1 Protein, Human, Recombinant (His)	Human	E. coli
	Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8.
TMPY-00717	CEACAM1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	CEACAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.8 kDa and the accession number is P13688-8.