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Orientin

Catalog No. T6S0721 CAS 28608-75-5

Synonyms: Lutexin, Luteolin-8-glucoside

1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. 3. Orientin has neuroprotection effect by the intracellular mediation of caspase activity; may alleviate cognitive deficits and oxidative stress in AD mice; can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.

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Orientin, CAS 28608-75-5

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 100.00
1 mL * 10 mM (in DMSO)	In stock	$ 60.00

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Purity: 99.68%

Purity: 99.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Polygonaceae > Polygonum

Synonyms	Lutexin, Luteolin-8-glucoside
Molecular Weight	448.38
Formula	C21H20O11
CAS No.	28608-75-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 81 mg/mL(180.7 mM)

Ethanol: Soluble

References and Literature

1. LAW, B., LING, A., KOH, R., CHYE, S., & WONG, Y. (2013). Neuroprotective effects of orientin on hydrogen peroxide-induced apoptosis in SH-SY5Y cells. Molecular Medicine Reports, 9(3), 947-954. doi: 10.3892/mmr.2013.1878 2. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051.

Citations

1. Jang S A, Hwang Y H, Yang H, et al. Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis. Biomedicine & Pharmacotherapy. 2022, 147: 112640. 2. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet. Molecules. 2019, 24(17): 3051 3. Jung M A, Song H K, Jo K, et al.Gleditsia sinensis Lam. aqueous extract attenuates nasal inflammation in allergic rhinitis by inhibiting MUC5AC production through suppression of the STAT3/STAT6 pathway.Biomedicine & Pharmacotherapy.2023, 161: 114482.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Tobacco Monomer Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Ferroptosis Compound Library Human Metabolite Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Flavonoid Natural Product Library Anti-Cancer Compound Library Anti-Tumor Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Orientin 28608-75-5 Others neuroprotective inhibit Inhibitor cardio protection Lutexin Luteolin-8-glucoside inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.