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Barlerin

Catalog No. T5S1632 CAS 57420-46-9

Synonyms: 8-O-Acetylshanzhiside methyl ester, ND01

Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway.

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Barlerin, CAS 57420-46-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 257.00
50 mg	In stock	$ 373.00
100 mg	In stock	$ 562.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 99.83%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Rubiaceae > Gardenia

Synonyms	8-O-Acetylshanzhiside methyl ester, ND01
Molecular Weight	448.42
Formula	C19H28O12
CAS No.	57420-46-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 82 mg/mL(182.9 mM)

References and Literature

1. Kang ZC, Jiang WL, et al.Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury.Send to 2. Zhang L, et al.8-O-acetyl shanzhiside methylester attenuates cerebral ischaemia/reperfusion injury through an anti-inflammatory mechanism in diabetic rats.Send to Basic Clin Pharmacol Toxicol. 2014 Dec;115(6):481-7. 3. Jiang WL, et al.Effect of 8-O-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke.Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):21-7.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Tyrosine Kinase Inhibitor Library Traditional Chinese Medicine Monomer Library Kinase Inhibitor Library RO5 Drug-like Natural Product Library HIF-1 Signaling Pathway Compound Library Anti-Diabetic Compound Library Selected Plant-Sourced Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Barlerin 57420-46-9 Angiogenesis Apoptosis Cytoskeletal Signaling NF-Κb PI3K/Akt/mTOR signaling Proteases/Proteasome Tyrosine Kinase/Adaptors Caspase VEGFR Akt NF-κB TNF inhibit Inhibitor ND-01 8-O-Acetylshanzhiside methyl ester Nuclear factor-κB ND 01 Nuclear factor-kappaB ND01 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.