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TC11

Catalog No. T9083 CAS 100823-03-8

Synonyms: CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11

TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

TC11, CAS 100823-03-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 369.00
100 mg	In stock	$ 549.00
500 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 93.00

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Purity: 98.1%

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Chemical Properties

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Description	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
In vivo	TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

Synonyms	CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11
Molecular Weight	322.4
Formula	C20H22N2O2
CAS No.	100823-03-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (139.57 mM)

References and Literature

1. Di A , Mn A , Wm A , et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells - ScienceDirect[J]. Biochemical and Biophysical Research Communications, 2020, 521( 1):252-258.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Kinase Inhibitor Library Inhibitor Library Pyroptosis Compound Library Bioactive Compounds Library Max Protease Inhibitor Library Anti-Cancer Compound Library Cell Cycle Compound Library NO PAINS Compound Library Apoptosis Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TC11 100823-03-8 Apoptosis Cell Cycle/Checkpoint Proteases/Proteasome BCL CDK Caspase Cyclin dependent kinase Apoptotic Mitotic CLT003 Inhibitor Immunomodulatory TC 11 CLT-003 CLT 003 Derivative inhibit Bcl-2 Family TC-11 Antitumor Phenylphthalimide 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 Death inhibitor

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