Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 200.00 | |
10 mg | In stock | $ 320.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 210.00 |
Description | Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK. |
In vitro | Treatment of C2C12 myoblasts with 500 nM dehydrocorydrine increased the expression level of muscle-specific proteins (including MyoD, myogenin and myosin heavy chain). Treatment with dehydrocorydrine can increase p38 MAPK activation and the interaction between MyoD and E protein. In addition, the treatment of dehydrohydroxyproline can restore the defects of differentiation-induced p38 MAPK activation and differentiation of myoblasts in C2C12 myoblasts induced by the differentiated early growth receptor protein Cdo. Dehydrohydroxyproline significantly inhibits the proliferation of MCF-7 cells in a dose-dependent manner, which can be reversed by the caspase-8 inhibitor Z-IETD-FMK. Dehydrohydroxyproline increases DNA fragments without affecting ΔΨm. Western blot analysis showed that dehydrocorydrine increased dose-dependently Bax protein expression and decreased Bcl-2 protein expression. In addition, dehydrohydroxyproline induces caspase-7,-8 activation and PARP cleavage without affecting caspase-9. These results indicate that dehydrohydroxyproline inhibits the proliferation of MCF-7 cells by inducing apoptosis by regulating Bax/Bcl-2, activating caspase and cleaving PARP. |
In vivo | Dehydrocobaltate (3.6, 6 or 10 mg/kg, intraperitoneal injection) showed a dose-dependent anti-nociceptive effect in the acetic acid-induced writhing test and significantly reduced formalin-induced mice Pain reaction. In the formalin test, dehydrocorydrine can reduce the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. It was confirmed that dehydroyanhusine has an analgesic effect on mice. |
Synonyms | 13-Methylpalmatine chloride |
Molecular Weight | 401.88 |
Formula | C22H24ClNO4 |
CAS No. | 10605-03-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24 mg/mL(59.72 mM)
You can also refer to dose conversion for different animals. More
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Dehydrocorydaline chloride 10605-03-5 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair MAPK Microbiology/Virology Proteases/Proteasome Caspase Parasite BCL PARP p38 MAPK inhibit Bcl-2 Family Dehydrocorydaline Chloride poly ADP ribose polymerase 13-Methylpalmatine Dehydrocorydaline 13-Methylpalmatine Chloride Inhibitor 13-Methylpalmatine chloride inhibitor