ca-3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4309	CIL56	CA3	Ferroptosis , ROS
	CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyuns...		Ferroptosis , ROS
T9027	CA-4948	Emavusertib	IRAK , FLT
	CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.		IRAK , FLT
T2782	Catharanthine	(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine	Calcium Channel , AChR
	Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).		Calcium Channel , AChR
T6212	Combretastatin A4	CA4,CRC 87-09	Microtubule Associated
	Combretastatin A4 (CA4) is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM).		Microtubule Associated
T40376	L-Phenylalanine-15N	(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N	Calcium Channel
	L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dep...		Calcium Channel
T3377	L-Phenylalanine	(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel , Endogenous Metabolite , iGluR
	L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.		Calcium Channel , Endogenous Metabolite , iGluR
T3915	Ginsenoside Ro	Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V	Calcium Channel , Reductase , Prostaglandin Receptor
	Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM.		Calcium Channel , Reductase , Prostaglandin Receptor
T1260	Cromolyn sodium	Disodium Cromoglycate,FPL 670 (Cromolyn) Disodium,FPL-670,Sodium cromoglycate	Others , Potassium Channel , GSK-3 , Calcium Channel
	Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.		Others , Potassium Channel , GSK-3 , Calcium Channel
T7550	Barnidipine	YM-09730-5(Free base),Mepirodipine	Calcium Channel
	Barnidipine (YM-09730-5(Free base)) is a calcium channel blocker.		Calcium Channel
T16564	PPADS tetrasodium		P2X Receptor , Na+/Ca2+ Exchanger
	PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in...		P2X Receptor , Na+/Ca2+ Exchanger
T4S1419	(±)-Praeruptorin A	Praeruptorin A,(-)-Praeruptorin A	p38 MAPK , Calcium Channel , Akt
	1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ...		p38 MAPK , Calcium Channel , Akt
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T6S2140	β-Anhydroicaritin	Anhydroicaritin,Beta-Anhydroicaritin	MMP , Others , TNF , Interleukin
	1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical ...		MMP , Others , TNF , Interleukin
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T67775	Enpp/Carbonic anhydrase-IN-1		PDE , Carbonic Anhydrase
	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectiv...		PDE , Carbonic Anhydrase
T61340	CAII-IN-3
	CAII-IN-3 (compound 3h) is a thiosemicarbazone derivative known for its potent inhibition of carbonic anhydrase-II (CA-II). It exhibits an IC50 value of 13.4 μM [1].
T63753	HCAIX-IN-3
	hCAII-IN-3 (compound 7e) is a selective and potent carbonic anhydrase (CA II/IX) inhibitors with their Kis values of 124.2 and 30.5 nM, respectively. hCAII-IN-1 has shown investigational potential for cancer disease.
T31573	DPX-3778
	DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin ...
T23102	OBAA		Others
	OBAA is a potent inhibitor of phospholipase A2 (PLA2) with an IC 50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC 50 of 0.4 μM [1] [2] [3].		Others
T75866	RFRP-3(human) TFA
	RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human homolog of the GnIH peptide, significantly suppresses gonadotropin release through inhibition of Ca 2+ mobilization. Acting as an NPFF1 receptor agonist, RFRP-3 (huma...