Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 315.00 | |
100 mg | In stock | $ 483.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 78.00 |
Description | CIL56 (CA3) is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro.HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death. |
Synonyms | CA3 |
Molecular Weight | 489.61 |
Formula | C23H27N3O5S2 |
CAS No. | 300802-28-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 88 mg/mL(179.7 mM)
You can also refer to dose conversion for different animals. More
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CIL56 300802-28-2 Apoptosis Immunology/Inflammation ROS Ferroptosis CA 3 Inhibitor inhibit CA3 CA-3 CIL 56 CIL-56 inhibitor