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OBAA

Name: OBAA
Brand: TargetMol
SKU: T23102
Rating: 4.5 (1 reviews)

Catalog No. T23102 Copy Product Info

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OBAA is a phospholipase inhibitor and a broad-spectrum PLA2 inhibitor. It exhibits potent anti-inflammatory activity by blocking arachidonic acid pathways, used for acute inflammation research.

OBAA

Copy Product Info

😃Good

Catalog No. T23102

OBAA is a phospholipase inhibitor and a broad-spectrum PLA2 inhibitor. It exhibits potent anti-inflammatory activity by blocking arachidonic acid pathways, used for acute inflammation research.

Cas No. 221632-26-4

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Product Introduction

Bioactivity

Description	OBAA is a phospholipase inhibitor and a broad-spectrum PLA2 inhibitor. It exhibits potent anti-inflammatory activity by blocking arachidonic acid pathways, used for acute inflammation research.
Targets&IC50	PLA2:70 nM
In vitro	OBAA (5.7 uM) induces apoptosis in HUVECs and regulates Ca2+ entry in T. brucei via PLA2 inhibition [1][2].
In vivo	Intravenous OBAA (2.5-7 mg/kg) significantly inhibits immunologically induced bronchospasm in guinea pig models [3].

Chemical Properties

Molecular Weight	428.65
Formula	C₂₈H₄₄O₃
Cas No.	221632-26-4
Smiles	C(CCCCCCCCCCCCCCCCC)C1=CC=C(C(/C=C/C(O)=O)=O)C=C1
Relative Density.	0.976 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (46.66 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3329 mL	11.6645 mL	23.3291 mL	116.6453 mL
5 mM	0.4666 mL	2.3329 mL	4.6658 mL	23.3291 mL
10 mM	0.2333 mL	1.1665 mL	2.3329 mL	11.6645 mL
20 mM	0.1166 mL	0.5832 mL	1.1665 mL	5.8323 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc