Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 328.00 | |
100 mg | In stock | $ 563.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 76.00 |
Description | CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. |
In vitro | CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines.?Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays.?CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.?CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure.?The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia[2]. |
Synonyms | Emavusertib |
Molecular Weight | 491.5 |
Formula | C24H25N7O5 |
CAS No. | 1801344-14-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 27.78 mg/mL (56.52 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CA-4948 1801344-14-8 Angiogenesis Immunology/Inflammation NF-Κb Tyrosine Kinase/Adaptors IRAK FLT rheumatoid inflammation CD135 inhibit IL-1R associated kinase CA4948 lymphoma Interleukin-1 receptor associated kinase Fms like tyrosine kinase 3 Emavusertib FLT3 arthritis Inhibitor Cluster of differentiation antigen 135 Myd88 CA 4948 IL-1R Toll inhibitor