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Crebanine

Catalog No. T2S2215 CAS 25127-29-1

1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease the incidence of VF and CA by CaCl_2 in rats and by chloroform in mice, but has no proteetive effects on ouahain-indueed arrhythmias in guinea pigs. 3. Crebanine has potential utility of crebanine in the development of neurodegenerative therapy, might be used as the starting point to develop a drug for Alzheimer's disease. 4. Crebanine has anti-cancer activity, can inhibit the proliferation of human leukemic cells (HL-6, U937 and K562), human fibrosarcoma cells (HT18) and cervix cancer cell lines (KB-3-1 and KB-V1; it mediates cell cycle arrest at G/G1 phase and this was associated with down-regulation of cyclins A and D.

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Crebanine, CAS 25127-29-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 96.00
10 mg	In stock	$ 165.00
25 mg	In stock	$ 319.00
50 mg	In stock	$ 479.00
100 mg	In stock	$ 688.00
500 mg	In stock	$ 1,420.00

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Purity: 99.65%

Purity: 99.17%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Menispermaceae > Stephania

Molecular Weight	339.39
Formula	C20H21NO4
CAS No.	25127-29-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62 mg/mL(182.7 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

References and Literature

1. Xiao-Shan H , Qing L , Yun-Shu M , et al. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes[J]. Chin J Nat Med, 2014.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Tumor Natural Product Library HIF-1 Signaling Pathway Compound Library Natural Product Library for HTS Anti-Lung Cancer Compound Library The Yao nationality medicine Library

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Keywords

Crebanine 25127-29-1 Apoptosis Cytoskeletal Signaling Others PI3K/Akt/mTOR signaling Akt PKB inhibit Protein kinase B Inhibitor inhibitor

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